SAP102 Antibody – Mouse Monoclonal

DLG3: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: postsynaptic membrane; extracellular space; growth cone; tight junction; cell soma; basolateral plasma membrane; cytoplasm; postsynaptic density; plasma membrane; synapse; intercellular junction; dendritic shaft

Molecular Function: protein C-terminus binding; protein domain specific binding; ionotropic glutamate receptor binding; guanylate kinase activity; protein binding; ubiquitin protein ligase binding; protein phosphatase binding; kinase binding; phosphatase binding; PDZ domain binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; synaptic transmission; nervous system development; embryonic development; establishment of planar polarity; receptor clustering; nucleotide phosphorylation