Mouse Anti-CACNB2 Monoclonal Antibody – Cat# MBS190548

Adult rat brain lysate.
A band of ~78kDa is detected.

Cav-Beta 2 Ca+2 Channel (CACNB2) Antibody – Mouse Monoclonal

Name: CACNB2 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS190548
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS190548

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Cavbeta subunits are involved in the transport… More details

$580 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cav-beta 2 Ca+2 Channel (Cacnb2), Monoclonal Antibody

Full Product Name

Anti-Cav beta 2 Ca+2 Channel Monoclonal Antibody

Product Gene Name

anti-Cacnb2 antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

S8b-1

Host

Mouse

Form/Format

1.0mg/ml in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.

Specificity

This antibody recognizes human, mouse, and rat Cavbeta2. It does not cross-react with Cav beta1, Cav beta3, or Cav beta4.

Preparation and Storage

This antibody is stable for at least one (1) year at -20°C. Avoid repeated freezing and thawing.

Chromosome Location

Chromosome: 17; NC_005116.2 (88832905..89078870). Location: 17q12.3

3D Structure

ModBase 3D Structure for Q8VGC3

Appearance

Clear Liquid

Antigen

Synthetic peptide corresponding to aa 189-205 of rat Cavbeta2 (RSPKPSANSVTSPHSKE) (accession no.NP_446303).

Dilution Instructions

Dilute in PBS or medium which is identical to that used in the assay system.

Applications Tested/Suitable for anti-Cacnb2 antibody

Immunoblot (IB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunofluorescence (IF)

Application Notes for anti-Cacnb2 antibody

Immunoblotting: use at 1-10ug/ml.
Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml.
Immunofluorescence: use at 1-10ug/ml.

These are recommended concentrations.
User should determine optimal concentrations for their application.
Positive control: Rat brain lysate

Other Notes

Small volumes of anti-Cacnb2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cacnb2 purchase

Ion channels like anti Cav beta 2 calcium channel - CACNB - are localized to cell plasma membrane and activation with ligands results in cellular responses. With limited information about molecular subunit composition for active voltage dependent calcium channels, MyBiosource's mouse monoclonal antibody recognized beta specifically and not gamma or alpha. Cell experiments to determine functional properties commonly utilize stable transfections of human or mouse gene plasmid lenti activation system expression or ShRNA plasmid sc knockdown. The ability to distinguish subtypes of expression in either stably puromycin type selection or stable gene silencing puromyocin selection requires our pan species [ human mouse rat ] CACNB2 antibody. Compared to rabbit antibodies, our Cav B2 calcium channel voltage antibody recognizes protein in lysates, IHC and is suitable for ELISA kits development. Value pricing, rapid shipping and promotional items make this product and all our products top sellers worldwide. Find us at MyBiosource.com.

Additional Details

NCBI/Uniprot data below describe general gene information for Cacnb2. It may not necessarily be applicable to this product.

NCBI GI #

16758716

NCBI GeneID

116600

NCBI Accession #

NP_446303.1

UniProt Primary Accession #

Q8VGC3

UniProt Secondary Accession #

Q811Q6; Q811Q7; Q91ZJ8; Q9QUU7

UniProt Related Accession #

Q8VGC3

GenBank Nucleotide #

NM_053851.1

NCBI Official Full Name

voltage-dependent L-type calcium channel subunit beta-2

NCBI Official Synonym Full Names

calcium channel, voltage-dependent, beta 2 subunit

NCBI Official Symbol

Cacnb2

NCBI Official Synonym Symbols

Cacnlb2

UniProt Protein Name

Voltage-dependent L-type calcium channel subunit beta-2

UniProt Synonym Protein Names

Calcium channel voltage-dependent subunit beta 2

Protein Family

Voltage-dependent L-type calcium channel

UniProt Gene Name

Cacnb2

UniProt Synonym Gene Names

Cacnlb2

UniProt Entry Name

CACB2_RAT

NCBI Protein Information

voltage-dependent L-type calcium channel subunit beta-2; CAB2; calcium channel voltage-dependent subunit beta 2

NCBI Summary for Cacnb2

auxillary subunit of the L-type Ca(2+) channel [RGD]

UniProt Comments for Cacnb2

CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Cellular Component: voltage-gated calcium channel complex; sarcolemma

Molecular Function: voltage-gated calcium channel activity; protein domain specific binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein kinase binding

Biological Process: synaptic transmission; visual perception; calcium ion transport; positive regulation of calcium ion transport; neuromuscular junction development

Research Articles on Cacnb2

1. This study provides the first evidence to demonstrate that LTCC beta2 subunit is coupled with the movement of signals in the mechanism of activation of NKA-mediated crosstalk with LTCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Cacnb2 antibody

Reference Product	PubMed Publications
Cacna1c antibody	>8 publications with Cacnb2 and Cacna1c
Cacna1a antibody	>4 publications with Cacnb2 and Cacna1a

Pathways associated with anti-Cacnb2 antibody

Products by Pathway	Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies	Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
Diabetes Pathways antibodies	Diabetes Pathways Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram

Diseases associated with anti-Cacnb2 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>7 publications with Cacnb2 and Nervous System Diseases
Brugada Syndrome Antibodies	>5 publications with Cacnb2 and Brugada Syndrome
Death, Sudden, Cardiac Antibodies	>4 publications with Cacnb2 and Death, Sudden, Cardiac
Congenital Abnormalities Antibodies	>2 publications with Cacnb2 and Congenital Abnormalities
Hypertension Antibodies	>2 publications with Cacnb2 and Hypertension
Myocardial Ischemia Antibodies	>1 publications with Cacnb2 and Myocardial Ischemia
Long QT Syndrome Antibodies	>1 publications with Cacnb2 and Long QT Syndrome
Lung Neoplasms Antibodies	>1 publications with Cacnb2 and Lung Neoplasms
Lung Diseases Antibodies	>1 publications with Cacnb2 and Lung Diseases
Carcinoma, Small Cell Antibodies	>1 publications with Cacnb2 and Carcinoma, Small Cell

Organs/Tissues associated with anti-Cacnb2 antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>12 publications with Cacnb2 and Heart
Brain Antibodies	>9 publications with Cacnb2 and Brain
Kidney Antibodies	>3 publications with Cacnb2 and Kidney
Inner Ear Antibodies	>1 publications with Cacnb2 and Inner Ear
Embryonic Tissue Antibodies	>1 publications with Cacnb2 and Embryonic Tissue