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VAMP-1,2/Synaptobrevin (VAMP1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS190554

VAMP-1 (Vesicle-Associated Membrane Protein) is an 18kDa member of the synaptobrevin family. It is expressed in neurons, neutrophils, and skeletal muscle cells and participates in vesicle fusion with the plasma membrane. Synaptobrevins, syntaxins, SNAP25 are… More details

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Product Overview

Product Name
VAMP-1,2/Synaptobrevin (VAMP1), Monoclonal Antibody
Full Product Name
Anti-VAMP-1,2/Synaptobrevin Monoclonal Antibody
Product Gene Name
Clonality
Monoclonal
Isotype
IgG1
Clone Number
SP-11
Host
Mouse
Species Reactivity
Human
Form/Format
100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Specificity
VAMP-1,2/Synaptobrevin
This antibody recognizes human VAMP1 and VAMP2.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
Molecular Weight
12,902 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (6571403..6579843, complement). Location: 12p
OMIM
185880
3D Structure
ModBase 3D Structure for P23763
Antigen
Crude human synaptic immunoprecipitate.
Dilution Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Applications Tested/Suitable for anti-VAMP1 antibody
Immunoblot
Application Notes for anti-VAMP1 antibody
Immunoblotting: use at 0.5-1.0ug/ml. A band of ~18kDa is detected. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Human brain lysate

Other Notes

Small volumes of anti-VAMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VAMP1 purchase

MBS190554 is an antibody targeting VAMP1. Also known as Anti-VAMP-1,2/Synaptobrevin Monoclonal Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for VAMP1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
vesicle-associated membrane protein 1 isoform 2
NCBI Official Synonym Full Names
vesicle-associated membrane protein 1 (synaptobrevin 1)
NCBI Official Symbol
VAMP1
NCBI Official Synonym Symbols
SYB1; VAMP-1; DKFZp686H12131
UniProt Protein Name
Vesicle-associated membrane protein 1
UniProt Synonym Protein Names
Synaptobrevin-1
UniProt Gene Name
VAMP1
UniProt Synonym Gene Names
SYB1
UniProt Entry Name
VAMP1_HUMAN
NCBI Protein Information
vesicle-associated membrane protein 1; synaptobrevin 1; synaptobrevin-1; OTTHUMP00000238453; OTTHUMP00000238454; OTTHUMP00000238455; OTTHUMP00000238560; OTTHUMP00000238561

NCBI Summary for VAMP1

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq]
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UniProt Comments for VAMP1

VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p

Cellular Component: SNARE complex; mitochondrial outer membrane; synaptic vesicle; neuron projection; cell surface; synaptic vesicle membrane; integral to plasma membrane; cytosol; cell junction

Molecular Function: SNAP receptor activity; SNARE binding; protein binding

Biological Process: vesicle fusion; exocytosis; pathogenesis

Disease: Spastic Ataxia 1, Autosomal Dominant
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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