• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Cav Beta 1 Ca +2 Channel (CACNB1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS190562

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Calcium channel, voltage-dependent, beta 1… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
Cav beta 1 Ca +2 Channel (Cacnb1), Monoclonal Antibody
Full Product Name
Anti-Cav beta 1 Ca+2 Channel Monoclonal Antibody
Product Gene Name
anti-Cacnb1 antibody
Clonality
Monoclonal
Isotype
lgG2a
Clone Number
S7-18
Host
Mouse
Species Reactivity
Human, mouse, rat
Form/Format
100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Specificity
Cav beta 1Ca +2 Channel
This antibody recognizes human, mouse, and rat Cav21. It does not cross-react with,"* 24.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
Molecular Weight
65,680 Da
Immunogen Sequence Positions
19-34
Chromosome Location
Chromosome: 10; NC_005109.2 (86764283..86784791, complement). Location: 10q31
3D Structure
ModBase 3D Structure for P54283
Antigen
Synthetic peptide corresponding to aa 19-34 of rat Cav21 (gene accession no. NP_059042).
Dilution Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Applications Tested/Suitable for anti-Cacnb1 antibody
Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence
Application Notes for anti-Cacnb1 antibody
Immunoblotting: use at 1ug/ml. Bands of -55 and 80kDa are detected. Immunohistochemistry and Immunocytochemistry. use at 0.1-1 ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate

Other Notes

Small volumes of anti-Cacnb1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cacnb1 purchase

MBS190562 is an antibody targeting Cacnb1. Also known as Anti-Cav beta 1 Ca+2 Channel Monoclonal Antibody. Reactive in Human, mouse, rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Cacnb1. It may not necessarily be applicable to this product.

NCBI GI #
8393060
NCBI GeneID
50688
NCBI Accession #
NP_059042.1
UniProt Primary Accession #
P54283
UniProt Related Accession #
P54283
GenBank Nucleotide #
NM_017346.1
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit beta-1
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, beta 1 subunit
NCBI Official Symbol
Cacnb1
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit beta-1
UniProt Synonym Protein Names
Calcium channel voltage-dependent subunit beta 1
Protein Family
Voltage-dependent L-type calcium channel
UniProt Gene Name
Cacnb1
UniProt Synonym Gene Names
Cacnlb1
UniProt Entry Name
CACB1_RAT
NCBI Protein Information
voltage-dependent L-type calcium channel subunit beta-1; CAB1; calcium channel beta 1 subunit; brain calcium channel beta 1 subunit; calcium channel voltage-dependent subunit beta 1

NCBI Summary for Cacnb1

may act as a regulatory component of a neuronal calcium channel [RGD]

UniProt Comments for Cacnb1

CACNB1: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Cellular Component: sarcoplasmic reticulum; cell; T-tubule; voltage-gated calcium channel complex; intracellular; sarcolemma

Molecular Function: voltage-gated calcium channel activity; protein domain specific binding; protein binding; high voltage-gated calcium channel activity; phosphoprotein binding; protein kinase binding

Biological Process: synaptic transmission; calcium ion transport; protein targeting to membrane; neuromuscular junction development
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Cacnb1 antibody

 Reference Product  PubMed Publications
 Cacna1c antibody  >1 publications with Cacnb1 and Cacna1c
 Cacna1a antibody  >1 publications with Cacnb1 and Cacna1a

Pathways associated with anti-Cacnb1 antibody

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram

Diseases associated with anti-Cacnb1 antibody

 Disease Name  Pubmed Publications
 Neurologic Manifestations Antibodies  >2 publications with Cacnb1 and Neurologic Manifestations
 Acidosis Antibodies  >1 publications with Cacnb1 and Acidosis

Organs/Tissues associated with anti-Cacnb1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >8 publications with Cacnb1 and Muscle
 Brain Antibodies  >3 publications with Cacnb1 and Brain
 Inner Ear Antibodies  >1 publications with Cacnb1 and Inner Ear
 Heart Antibodies  >1 publications with Cacnb1 and Heart
 Dorsal Root Ganglion Antibodies  >1 publications with Cacnb1 and Dorsal Root Ganglion
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000