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Kir2.3 K+ Channel (KCNJ4) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS190581

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. The protein encoded by the Kir2.3 gene is an… More details

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Product Overview

Product Name
Kir2.3 K+ Channel (Kcnj4), Monoclonal Antibody
Full Product Name
Anti-Kir2.3 K+ Monoclonal Antibody
Product Gene Name
anti-Kcnj4 antibody
Clonality
Monoclonal
Isotype
lgG1
Clone Number
S25-35
Host
Mouse
Species Reactivity
Human, mouse, rat
Form/Format
100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Specificity
Kir2.3 K+ Channel
This antibody recognizes human, mouse, and rat Kir2.3. It does not cross-react with Kir2.1 orKir2.2.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
Molecular Weight
49,899 Da
Immunogen Sequence Positions
390-445
Chromosome Location
Chromosome: 15; NC_000081.5 (79314144..79335671, complement). Location: 15 E1; 15 46.7 cM
3D Structure
ModBase 3D Structure for P52189
Antigen
Fusion protein aa 390-445 of human Kir2.3 (accession number NP_032453).
Dilution Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Applications Tested/Suitable for anti-Kcnj4 antibody
Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence
Application Notes for anti-Kcnj4 antibody
Immunoblotting: use at 1-10ug/ml. A band of ~45kDa is detected. Immunohistochemistry and Immunocytochemistry. use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate.

Other Notes

Small volumes of anti-Kcnj4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Kcnj4 purchase

MBS190581 is an antibody targeting Kcnj4. Also known as Anti-Kir2.3 K+ Monoclonal Antibody. Reactive in Human, mouse, rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcnj4. It may not necessarily be applicable to this product.

NCBI GI #
158711668
NCBI GeneID
16520
NCBI Accession #
NP_032453.3
UniProt Primary Accession #
P52189
UniProt Related Accession #
P52189; Q8R434; Q8R435; Q9QYK8
GenBank Nucleotide #
NM_008427.4
NCBI Official Full Name
inward rectifier potassium channel 4
NCBI Official Synonym Full Names
potassium inwardly-rectifying channel, subfamily J, member 4
NCBI Official Symbol
Kcnj4
NCBI Official Synonym Symbols
IRK3; Kcnf2; MB-IRK3
UniProt Protein Name
Inward rectifier potassium channel 4
UniProt Synonym Protein Names
Inward rectifier K(+) channel Kir2.3; IRK-3; Potassium channel, inwardly rectifying subfamily J member 4
Protein Family
Inward rectifier potassium channel
UniProt Gene Name
Kcnj4
UniProt Synonym Gene Names
Irk3
UniProt Entry Name
IRK4_MOUSE
NCBI Protein Information
inward rectifier potassium channel 4; IRK-3; Kir 2.3; inward rectifier K(+) channel Kir2.3; potassium channel, inwardly rectifying subfamily J member 4

UniProt Comments for Kcnj4

HIR: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral

Cellular Component: postsynaptic membrane; membrane; cell soma; basolateral plasma membrane; integral to plasma membrane; dendrite; plasma membrane; integral to membrane; synapse; cytoplasmic vesicle; cell junction

Molecular Function: voltage-gated ion channel activity; inward rectifier potassium channel activity; PDZ domain binding

Biological Process: potassium ion import; transport; ion transport; potassium ion transport
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Research Articles on Kcnj4

1. modulated by mechanical deformation of ventricular myocytes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Kcnj4 antibody

 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 GABA B Receptor Activation Pathway antibodies  GABA B Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway antibodies  Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram

Organs/Tissues associated with anti-Kcnj4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with Kcnj4 and Brain
 Embryonic Tissue Antibodies  >2 publications with Kcnj4 and Embryonic Tissue
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