Mouse Anti-KCNT1 Monoclonal Antibody – Cat# MBS190600

Slo2.2 Sodium-Activated K+ Channel (KCNT1) Antibody – Mouse Monoclonal

Name: KCNT1 Antibody; Monoclonal; Mouse; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS190600
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS190600

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Slo2.2 is a sodium-activated potassium channel.… More details

$580 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Slo2.2 Sodium-Activated K+ Channel (Kcnt1), Monoclonal Antibody

Full Product Name

Anti-Slo2.2 Sodium-Activated K+ Channel Monoclonal Antibody

Product Gene Name

anti-Kcnt1 antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

S3-26

Host

Mouse

Species Reactivity

Human, mouse, rat

Purity/Purification

Protein G purified

Concentration

1.0 mg/ml in PBS, pH 7.4 (lot specific)

Specificity

Slo2.2 Sodium-Activated K+ Channel
This antibody recognizes human (weak), mouse, and rat Slo2.2.

Preparation and Storage

This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.

Chromosome Location

Chromosome: 3; NC_005102.2 (4050340..4088029). Location: 3p13

3D Structure

ModBase 3D Structure for Q9Z258

Preservative

50% Glycerol, 0.09 NaN3

Antigen

Fusion protein corresponding to aa 1168-1237 of rat Slo2.2 (accession no. NP_068625). This sequence is 94% homologous with human and 98% homologous with mouse Slo2.2.

Appearance

Clear Liquid

Dilution Instructions

Dilute in PBS or medium which is identical to that used in the assay system.

Applications Tested/Suitable for anti-Kcnt1 antibody

Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence

Application Notes for anti-Kcnt1 antibody

Immunoblotting: use at 1-10ug/ml. A band of ~140kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate.

Other Notes

Small volumes of anti-Kcnt1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Kcnt1 purchase

MBS190600 is an antibody targeting Kcnt1. Also known as Anti-Slo2.2 Sodium-Activated K+ Channel Monoclonal Antibody. Reactive in Human, mouse, rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcnt1. It may not necessarily be applicable to this product.

NCBI GI #

11177892

NCBI GeneID

60444

NCBI Accession #

NP_068625.1

UniProt Primary Accession #

Q9Z258

UniProt Secondary Accession #

Q5D6C6

UniProt Related Accession #

Q9Z258

GenBank Nucleotide #

NM_021853.1

NCBI Official Full Name

potassium channel subfamily T member 1

NCBI Official Synonym Full Names

potassium channel, subfamily T, member 1

NCBI Official Symbol

Kcnt1

NCBI Official Synonym Symbols

Slack; rSlo2

UniProt Protein Name

Potassium channel subfamily T member 1

UniProt Synonym Protein Names

Sequence like a calcium-activated potassium channel subunit

Protein Family

Potassium channel subfamily

UniProt Gene Name

Kcnt1

UniProt Synonym Gene Names

Slack

UniProt Entry Name

KCNT1_RAT

NCBI Protein Information

potassium channel subfamily T member 1; potassium channel subunit (Slack); sequence like a calcium-activated potassium channel subunit

NCBI Summary for Kcnt1

Na(+)-activated potassium channel; may be involved in regulating the firing properties of neurons [RGD]

UniProt Comments for Kcnt1

KCNT1: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Cellular Component: voltage-gated potassium channel complex; membrane; integral to membrane

Molecular Function: voltage-gated potassium channel activity; calcium-activated potassium channel activity; potassium channel activity

Biological Process: potassium ion transport

Research Articles on Kcnt1

1. phosphorylation by protein kinase A does not acutely modulate the function and gating activation kinetics of Slack channels

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-Kcnt1 antibody

Organ/Tissue Name	Pubmed Publications
Dorsal Root Ganglion Antibodies	>1 publications with Kcnt1 and Dorsal Root Ganglion