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Sodium Iodide Symporter (NIS) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS190650

The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells. This is an important step in the process of iodide organification and the formation of triiodothyronine and… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Sodium Iodide Symporter (NIS), Monoclonal Antibody
Full Product Name
Sodium Iodide Symporter Monoclonal Antibody
Product Gene Name
anti-NIS antibody
Product Synonym Names
Anti-Sodium Iodine Symporter
Clonality
Monoclonal
Isotype
IgG1
Host
Mouse
Specificity
This antibody recognizes human, mouse and rat NIS.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
Molecular Weight
68,666 Da
OMIM
274400
Antigen
Fusion protein consisting of aa468-643 of human NIS attached to mannose binding protein (MBP).
Positive Control
Graves disease-thyroid tissue.
Dilution Instructions
Dilute in PBS or medium which is identical to that used in the assay system.

Product Categories/Family for anti-NIS antibody

Ion Channel Antibodies
Applications Tested/Suitable for anti-NIS antibody
Immunoblot (IB), Immunohistochemistry (IHC)
Application Notes for anti-NIS antibody
Immunoblotting: Use at 1ug/ml. A major band of ~97kDa is detected. Depending on the sample, some minor bands may be detected as well.
Immunohistochemistry: Use at 1-10ug/ml

Testing Data of anti-NIS antibody

Mouse Anti-NIS Monoclonal Antibody – Cat# MBS190650

Other Notes

Small volumes of anti-NIS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NIS purchase

MBS190650 is an antibody targeting NIS. Also known as Sodium Iodide Symporter Monoclonal Antibody. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for NIS. It may not necessarily be applicable to this product.

NCBI GI #
1628579
NCBI GeneID
6528
NCBI Accession #
AAB17378.1
UniProt Secondary Accession #
O43702; Q2M335; Q9NYB6
UniProt Related Accession #
Q92911
NCBI Official Full Name
sodium iodide symporter
NCBI Official Synonym Full Names
solute carrier family 5 member 5
NCBI Official Symbol
SLC5A5
NCBI Official Synonym Symbols
NIS; TDH1
UniProt Protein Name
Sodium/iodide cotransporter
UniProt Synonym Protein Names
Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5
Protein Family
Sodium/iodide cotransporter
UniProt Gene Name
SLC5A5
UniProt Synonym Gene Names
NIS; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter
UniProt Entry Name
SC5A5_HUMAN
NCBI Protein Information
sodium/iodide cotransporter

NCBI Summary for NIS

This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]
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UniProt Comments for NIS

SLC5A5: Mediates iodide uptake in the thyroid gland. Defects in SLC5A5 are the cause of thyroid dyshormonogenesis 1 (TDH1). A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: integral to membrane; integral to plasma membrane; nucleus; plasma membrane

Molecular Function: iodide transmembrane transporter activity; sodium:iodide symporter activity

Biological Process: iodide transport; ion transport; thyroid hormone generation; transport

Disease: Thyroid Dyshormonogenesis 1
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Research Articles on NIS

1. Our results confirmed that NIS overexpression enhances the sensitivity of ER-negative breast cancer cells to radioiodide therapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NIS antibody

 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Organic Anion Transporters Pathway antibodies  Organic Anion Transporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroxine (Thyroid Hormone) Production Pathway antibodies  Thyroxine (Thyroid Hormone) Production Pathway Diagram
 Thyroxine Biosynthesis Pathway antibodies  Thyroxine Biosynthesis Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-NIS antibody

 Disease Name  Pubmed Publications
 Thyroid Diseases Antibodies  >10 publications with NIS and Thyroid Diseases
 Thyroid Neoplasms Antibodies  >8 publications with NIS and Thyroid Neoplasms
 Liver Diseases Antibodies  >2 publications with NIS and Liver Diseases
 Breast Neoplasms Antibodies  >2 publications with NIS and Breast Neoplasms
 Prenatal Injuries Antibodies  >1 publications with NIS and Prenatal Injuries
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with NIS and Prenatal Exposure Delayed Effects
 Prostatic Neoplasms Antibodies  >1 publications with NIS and Prostatic Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with NIS and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with NIS and Liver Neoplasms
 Cognition Disorders Antibodies  >1 publications with NIS and Cognition Disorders

Organs/Tissues associated with anti-NIS antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with NIS and Brain
 Muscle Antibodies  >1 publications with NIS and Muscle
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