Excitatory Amino Acid Transporter 1 (EAATs) Antibody – Mouse Monoclonal

This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]

SLC1A3: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: basolateral plasma membrane; cell soma; cell surface; dendritic spine; fibril; integral to membrane; membrane; mitochondrial inner membrane; plasma membrane

Molecular Function: amino acid transmembrane transporter activity; glutamate binding; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; sodium:dicarboxylate symporter activity

Biological Process: auditory behavior; cranial nerve development; gamma-aminobutyric acid biosynthetic process; glutamate biosynthetic process; glutamate secretion; ion transport; L-glutamate import; malate-aspartate shuttle; neuromuscular process controlling balance; neuron morphogenesis during differentiation; neurotransmitter uptake; positive regulation of defense response to virus by host; positive regulation of synaptic transmission; response to antibiotic; response to drug; response to light stimulus; response to wounding; sensory perception of sound; synaptic transmission

Disease: Episodic Ataxia, Type 6