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ATG13 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS191008

Background: Autophagy is a catabolic process that results in the degradation of bulk cytoplasmic contents within autophagosomes and lysosomes. Atg13 is a target of the TOR kinase signaling pathway that regulates autophagy through the control of the… More details

$580 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Atg13, Polyclonal Antibody
Full Product Name
Atg13
Product Gene Name
anti-Atg13 antibody
Clonality
Polyclonal
Host
Rabbit
Form/Format
Clear Liquid; Peptide affinity-purified antibody in PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Concentration
1mg/ml (lot specific)
Specificity
This antibody recognizes human Atg13.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Molecular Weight
60,155 Da
OMIM
AB014552 mRNA
3D Structure
ModBase 3D Structure for O75143
Antigen
Synthetic peptide corresponding to mid-protein amino acids of human Atg13.
Preservative
0.50% glycerol, 0.09% NaN3
Applications Tested/Suitable for anti-Atg13 antibody
Immunoblotting (IB), Immunofluorescence (IF)
Application Notes for anti-Atg13 antibody
Immunoblotting: use at 1-2ug/ml. A band of ~56-63kDa is detected.
Immunofluorescence: use at 10ug/ml.
Dilute in PBS or medium that is identical to that used in the assay system
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications

Immunofluorescence (IF) of anti-Atg13 antibody

Detection of Atg13 in formaldehyde-fixed C2C12 cells
Rabbit Anti-ATG13 Polyclonal Antibody – Cat# MBS191008

Testing Data of anti-Atg13 antibody

Detection of Atg13 in HEK 293 cell lysate.
Rabbit Anti-ATG13 Polyclonal Antibody, Testing Data – Cat# MBS191008

Other Notes

Small volumes of anti-Atg13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Atg13 purchase

MBS191008 is an antibody targeting Atg13. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Atg13. It may not necessarily be applicable to this product.

NCBI GI #
218082953
NCBI GeneID
9776
NCBI Accession #
NP_001136145.1
UniProt Primary Accession #
O75143
UniProt Secondary Accession #
Q53EN6; Q9BRL3; Q9H8B0; B4DFI4; D3DQQ1; D3DQQ2; E9PQZ8
UniProt Related Accession #
O75143
GenBank Nucleotide #
NM_001142673.2
NCBI Official Full Name
autophagy-related protein 13 isoform c
NCBI Official Synonym Full Names
autophagy related 13
NCBI Official Symbol
ATG13
NCBI Official Synonym Symbols
KIAA0652; PARATARG8
UniProt Protein Name
Autophagy-related protein 13
Protein Family
Autophagy protein
UniProt Gene Name
ATG13
UniProt Synonym Gene Names
KIAA0652
NCBI Protein Information
autophagy-related protein 13

NCBI Summary for Atg13

The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]

UniProt Comments for Atg13

ATG13: an autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. Phosphorylated by ULK1 and ULK2. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 and -2 via C-terminus. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Vesicle

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: cytosol; mitochondrion

Molecular Function: protein binding; protein kinase binding

Biological Process: autophagic vacuole formation; macroautophagy
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Research Articles on Atg13

1. Structure of the human Atg13-Atg101 HORMA heterodimer in the ULK1 complex that controls autophagy has been described.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Atg13 antibody

 Products by Pathway  Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram

Diseases associated with anti-Atg13 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >5 publications with Atg13 and Kidney Diseases
 Neurologic Manifestations Antibodies  >2 publications with Atg13 and Neurologic Manifestations
 Nervous System Diseases Antibodies  >2 publications with Atg13 and Nervous System Diseases
 Breast Neoplasms Antibodies  >2 publications with Atg13 and Breast Neoplasms
 Embryo Loss Antibodies  >1 publications with Atg13 and Embryo Loss
 Cell Transformation, Neoplastic Antibodies  >1 publications with Atg13 and Cell Transformation, Neoplastic
 Hypertrophy Antibodies  >1 publications with Atg13 and Hypertrophy
 Atrophy Antibodies  >1 publications with Atg13 and Atrophy
 Necrosis Antibodies  >1 publications with Atg13 and Necrosis

Organs/Tissues associated with anti-Atg13 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >5 publications with Atg13 and Kidney
 Vascular Antibodies  >4 publications with Atg13 and Vascular
 Muscle Antibodies  >4 publications with Atg13 and Muscle
 Blood Antibodies  >2 publications with Atg13 and Blood
 Salivary Gland Antibodies  >1 publications with Atg13 and Salivary Gland
 Liver Antibodies  >1 publications with Atg13 and Liver
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