PDK1 Antibody – Rabbit Polyclonal

PDK1: an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described.

Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Nuclear receptor co-regulator; PKB family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cell projection; cytoplasm; cytosol; intracellular; nucleoplasm; plasma membrane

Molecular Function: 3-phosphoinositide-dependent protein kinase activity; kinase activity; phospholipase activator activity; phospholipase binding; protein binding; protein serine/threonine kinase activity

Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase B; calcium-mediated signaling; cell migration; cellular response to insulin stimulus; epidermal growth factor receptor signaling pathway; negative regulation of protein kinase activity; negative regulation of transforming growth factor beta receptor signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphoinositide-mediated signaling; platelet activation; positive regulation of release of sequestered calcium ion into cytosol; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of I-kappaB kinase/NF-kappaB cascade; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway