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STAT6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS191063

Signal transducers and activators of transcription (STATs) are transcription factors that play important roles in signaling pathways induced by many different cytokines and growth factors that regulate cell growth and differentiation, the immune response,… More details

$465 / 0.1 mL +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
STAT6, Polyclonal Antibody
Full Product Name
STAT6 (phospho-Thr645)
Product Gene Name
Clonality
Polyclonal
Host
Rabbit
Form/Format
100ul at 1.0mg/ml in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Affinity-purified on phosphopeptide; non-phosphopeptide- reactive antibodies were removed by chromatography on non-phosphorylated peptide.
Specificity
This antibody detects endogenous human STAT6 only when phosphorylated at threonine 645.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Can be stored at 4 degree C for short-term use.
Molecular Weight
81,748 Da
OMIM
U16031 mRNA
3D Structure
ModBase 3D Structure for P42226
Antigen
Peptide sequence that includes phosphorylation site of threonine 645 (P-A-T(p)-I-K) derived from human STAT6 and conjugated to KLH.
Applications Tested/Suitable for anti-STAT6 antibody
Immunoblotting (IB), Immunohistochemistry (IHC)
Application Notes for anti-STAT6 antibody
Immunoblotting: use at dilution of 1:500-1:1,000. A band of~110kDa is detected.
Immunohistochemistry: use at dilution of 1:50- 1:100.
Dilute in PBS or medium that is identical to that used in the assay system.

Immunohistochemistry (IHC) of anti-STAT6 antibody

Rabbit Anti-STAT6 Polyclonal Antibody – Cat# MBS191063

Testing Data of anti-STAT6 antibody

Rabbit Anti-STAT6 Polyclonal Antibody, Testing Data – Cat# MBS191063

Other Notes

Small volumes of anti-STAT6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STAT6 purchase

MBS191063 is an antibody targeting STAT6. Also known as STAT6 (phospho-Thr645). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
signal transducer and activator of transcription 6 isoform 1
NCBI Official Synonym Full Names
signal transducer and activator of transcription 6
NCBI Official Symbol
STAT6
NCBI Official Synonym Symbols
STAT6B; STAT6C; D12S1644; IL-4-STAT
UniProt Protein Name
Signal transducer and activator of transcription 6
UniProt Synonym Protein Names
IL-4 Stat
UniProt Gene Name
STAT6
NCBI Protein Information
signal transducer and activator of transcription 6

NCBI Summary for STAT6

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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UniProt Comments for STAT6

STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: identical protein binding; protein binding; protein phosphatase binding

Biological Process: positive regulation of interferon type I production; regulation of transcription from RNA polymerase II promoter; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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