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PINK1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS191332

PINK1 (PTEN-induced putative kinase 1) is a mitochondrial serine/threonine kinase that maintains mitochondrial function and integrity, provides protection against mitochondrial dysfunction during cellular stress, and is involved in the clearance of damaged… More details

$580 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PINK1, Monoclonal Antibody
Full Product Name
PINK1 Monoclonal Antibody
Product Gene Name
anti-PINK1 antibody
Clonality
Monoclonal
Isotype
IgG1
Host
Mouse
Form/Format
100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.
Specificity
This antibody recognizes human, mouse, and rat PINK1.
Preparation and Storage
This product is stable for at least one (1) year at-20 degree C.
Molecular Weight
30,104 Da
3D Structure
ModBase 3D Structure for Q9BXM7
Immunogen
Fusion protein corresponding to aa 112-496 (cytoplasmic C-terminus) of human PINK1. This sequence is 82% identical to rat PINK1 and 81% identical to mouse PINK1.
Applications Tested/Suitable for anti-PINK1 antibody
Immunoblot, Immunofluorescence (IF)
Application Notes for anti-PINK1 antibody
Immunoblot: 1-5ug/ml. A band of ~50kDa is detected.
IF: 10ug/ml
Dilute in PBS or medium that is identical to that used in the assay system.

Testing Data of anti-PINK1 antibody

Detection of PINK1 in 15ug rat brain lysate at 5ug/ml.
Mouse Anti-PINK1 Monoclonal Antibody – Cat# MBS191332

Testing Data of anti-PINK1 antibody

Detection of PINK1 is neuroblastoma cell line SKN-BE at 10ug/ml: DAPI (blue) nuclear stain, Texas RedF actin stain, FITC (green) PINK1 stain.
Mouse Anti-PINK1 Monoclonal Antibody, Testing Data – Cat# MBS191332

Other Notes

Small volumes of anti-PINK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PINK1 purchase

MBS191332 is an antibody targeting PINK1. Also known as PINK1 Monoclonal Antibody. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PINK1. It may not necessarily be applicable to this product.

NCBI GI #
14165272
NCBI GeneID
65018
NCBI Accession #
NP_115785.1
UniProt Primary Accession #
Q9BXM7
UniProt Secondary Accession #
Q8N6T9; Q8NBU3; Q96DE4
UniProt Related Accession #
Q9BXM7
GenBank Nucleotide #
NM_032409.2
NCBI Official Full Name
serine/threonine-protein kinase PINK1, mitochondrial
NCBI Official Synonym Full Names
PTEN induced kinase 1
NCBI Official Symbol
PINK1
NCBI Official Synonym Symbols
BRPK; PARK6
UniProt Protein Name
Serine/threonine-protein kinase PINK1, mitochondrial
UniProt Synonym Protein Names
BRPK; PTEN-induced putative kinase protein 1
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
PINK1
NCBI Protein Information
serine/threonine-protein kinase PINK1, mitochondrial

NCBI Summary for PINK1

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

UniProt Comments for PINK1

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 ().
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Research Articles on PINK1

1. PINK1 detection could help stratify patients who may have poor response to chemotherapy and guide the individual treatment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PINK1 antibody

 Reference Product  PubMed Publications
 PARK2 antibody  >527 publications with PINK1 and PARK2
 PARK7 antibody  >105 publications with PINK1 and PARK7
 ATP13A2 antibody  >47 publications with PINK1 and ATP13A2
 HTRA2 antibody  >22 publications with PINK1 and HTRA2
 TRAP1 antibody  >10 publications with PINK1 and TRAP1
 CDC37 antibody  >3 publications with PINK1 and CDC37
 FABP4 antibody  >1 publications with PINK1 and FABP4
 RICTOR antibody  >1 publications with PINK1 and RICTOR

Pathways associated with anti-PINK1 antibody

 Products by Pathway  Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram

Diseases associated with anti-PINK1 antibody

 Disease Name  Pubmed Publications
 Parkinson Disease Antibodies  >516 publications with PINK1 and Parkinson Disease
 Movement Disorders Antibodies  >503 publications with PINK1 and Movement Disorders
 Parkinsonian Disorders Antibodies  >498 publications with PINK1 and Parkinsonian Disorders
 Neurodegenerative Diseases Antibodies  >482 publications with PINK1 and Neurodegenerative Diseases
 Inflammation Antibodies  >19 publications with PINK1 and Inflammation
 Neuroblastoma Antibodies  >19 publications with PINK1 and Neuroblastoma
 Nerve Degeneration Antibodies  >18 publications with PINK1 and Nerve Degeneration
 Necrosis Antibodies  >17 publications with PINK1 and Necrosis
 Parkinson Disease 6, Autosomal Recessive Early-Onset Antibodies  >11 publications with PINK1 and Parkinson Disease 6, Autosomal Recessive Early-Onset
 Heart Diseases Antibodies  >11 publications with PINK1 and Heart Diseases

Organs/Tissues associated with anti-PINK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >209 publications with PINK1 and Brain
 Muscle Antibodies  >54 publications with PINK1 and Muscle
 Nerve Antibodies  >51 publications with PINK1 and Nerve
 Blood Antibodies  >23 publications with PINK1 and Blood
 Heart Antibodies  >17 publications with PINK1 and Heart
 Lung Antibodies  >12 publications with PINK1 and Lung
 Liver Antibodies  >11 publications with PINK1 and Liver
 Eye Antibodies  >11 publications with PINK1 and Eye
 Ganglia Antibodies  >11 publications with PINK1 and Ganglia
 Kidney Antibodies  >9 publications with PINK1 and Kidney
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