Nf Kappa B, P50 Antibody – Rabbit Polyclonal

Nuclear factor kappaB (NFkappaB) was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of the kappa light chain gene in B lymphocytes. NFkappaB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkappaB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection, NFkappaB is phosphorylated and degraded by the proteosome. The active NFkappaB heterodimer is translocated into the nucleus and induces gene expression.

Small volumes of anti-NF Kappa B, p50 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS191468 is an antibody targeting NF Kappa B, p50. Also known as Anti-NFkappaB, p50 Antibody. Host: Rabbit.