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CCL3 (MIP-1alpha) (CCL3) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS191496

CCL3, also known as Macrophage Inflammatory Protein-1alpha (MIP-1alpha), is a proinflammatory chemokine that stimulates chemotaxis and activation of different cell populations of the immune system. CCL3 binds to CCR1, CCR4, and CCR5 receptors, and it is one… More details

$300 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCL3 (MIP-1alpha), Active Protein
Full Product Name
Recombinant CCL3 (MIP-1alpha), biotinylated
Product Gene Name
CCL3 active protein
Product Synonym Names
Human CCL3, biotinylated
Sequence
SLAADTPTAC CFSYTSRQIP QNFIADYFET SSQCSKPGVI FLTKRSRQV CADPSEEWVQ KYVSDLELSA
Host
E Coli
Form/Format
Lyophilized
Purity/Purification
>97% by SDS-PAGE
Preparation and Storage
12 months from date of receipt,-20 degree C to-70 degree C, as supplied.
1 month,-20 degree C to-70 degree C, under sterile conditions after reconstitution.
Best if used immediately after reconstitution.
Avoid multiple freeze-thaw cycles.
Molecular Weight
10,085 Da
3D Structure
ModBase 3D Structure for P10147
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Source
Human
Endotoxin
<0.01 EU per 1ug of protein by LAL method.
Activity
EC50 = 1.1-2.6nM determined by Migration Assay of recombinant CCR5-expressing cells.
Modification
Biotinylated
Reconstitution
Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
Carrier Protein
None

Other Notes

Small volumes of CCL3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL3 purchase

MBS191496 is an active protein targeting CCL3. Also known as Recombinant CCL3 (MIP-1alpha), biotinylated. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL3. It may not necessarily be applicable to this product.

NCBI GI #
4506843
NCBI GeneID
6348
NCBI Accession #
NP_002974.1
UniProt Primary Accession #
P10147
UniProt Related Accession #
P10147
GenBank Nucleotide #
NM_002983.2
NCBI Official Full Name
C-C motif chemokine 3
NCBI Official Synonym Full Names
C-C motif chemokine ligand 3
NCBI Official Symbol
CCL3
NCBI Official Synonym Symbols
MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
UniProt Protein Name
C-C motif chemokine 3
UniProt Synonym Protein Names
G0/G1 switch regulatory protein 19-1; Macrophage inflammatory protein 1-alpha; MIP-1-alpha
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL3
UniProt Synonym Gene Names
G0S19-1; MIP1A; SCYA3; MIP-1-alpha
NCBI Protein Information
C-C motif chemokine 3

NCBI Summary for CCL3

This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
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UniProt Comments for CCL3

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

Research Articles on CCL3

1. During early remission from methamphetamine (MA), model mice exhibited increased anxiety-like behavior and reduced expression of chemokine (C-C motif) ligand 3 (ccl3) in the hippocampus relative to saline-treated mice. Human adults actively dependent on MA and those in early remission had elevated symptoms of anxiety as well as reductions in plasma levels of CCL3, relative to adults with no history of MA abuse.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL3 active protein

 Reference Product  PubMed Publications
 CCL4 active protein  >1620 publications with CCL3 and CCL4
 CCR5 active protein  >507 publications with CCL3 and CCR5
 CCR1 active protein  >280 publications with CCL3 and CCR1
 CCR2 active protein  >137 publications with CCL3 and CCR2
 CCR3 active protein  >68 publications with CCL3 and CCR3
 CCR4 active protein  >46 publications with CCL3 and CCR4
 IL18 active protein  >20 publications with CCL3 and IL18
 IL1B active protein  >15 publications with CCL3 and IL1B
 IDE active protein  >5 publications with CCL3 and IDE
 CXCR5 active protein  >4 publications with CCL3 and CXCR5

Pathways associated with CCL3 active protein

 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with CCL3 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >893 publications with CCL3 and Inflammation
 Necrosis Antibodies  >506 publications with CCL3 and Necrosis
 Disease Models, Animal Antibodies  >314 publications with CCL3 and Disease Models, Animal
 Lung Diseases Antibodies  >238 publications with CCL3 and Lung Diseases
 HIV Infections Antibodies  >188 publications with CCL3 and HIV Infections
 Cardiovascular Diseases Antibodies  >173 publications with CCL3 and Cardiovascular Diseases
 Hypersensitivity Antibodies  >105 publications with CCL3 and Hypersensitivity
 Liver Diseases Antibodies  >95 publications with CCL3 and Liver Diseases
 Fibrosis Antibodies  >79 publications with CCL3 and Fibrosis
 Pneumonia Antibodies  >72 publications with CCL3 and Pneumonia

Organs/Tissues associated with CCL3 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1553 publications with CCL3 and Blood
 Lung Antibodies  >328 publications with CCL3 and Lung
 Brain Antibodies  >257 publications with CCL3 and Brain
 Liver Antibodies  >216 publications with CCL3 and Liver
 Kidney Antibodies  >85 publications with CCL3 and Kidney
 Heart Antibodies  >79 publications with CCL3 and Heart
 Intestine Antibodies  >56 publications with CCL3 and Intestine
 Eye Antibodies  >51 publications with CCL3 and Eye
 Uterus Antibodies  >19 publications with CCL3 and Uterus
 Pancreas Antibodies  >18 publications with CCL3 and Pancreas
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