CYFRA21-1 Antibody – Mouse Monoclonal

Background: CYFRA 21-1 is a fragment of cytokeratin 19 (CK19). CK19 is expressed in the unstratified or pseudostratified epithelium lining the bronchial tree, and overexpression of CK19 has been detected in many lung cancer tissue specimens. Accelerated CK19 degradation occurs in neoplastically transformed epithelial cells as a result of increased protease activity of caspase-3 (a regulator of the apoptosis cascade), and fragments, including CYFRA21-1, are released into the blood. Measurement of levels of serum CYFRA 21-1 is a useful and highly specific auxiliary test for identification of non-small cell lung cancer (NSCLC) as well as for identification of squamous cell carcinoma of the lung.

Small volumes of anti-CYFRA21-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS191619 is an antibody targeting CYFRA21-1. Also known as CYFRA21-1 Monoclonal Antibodies. Reactive in CYFRA21-1. Host: Mouse.