PLA2G4D Antibody – Rabbit

PLA2G4D: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Two isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.4; Phospholipase; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: cytoplasmic vesicle membrane; cytosol

Molecular Function: phospholipase A2 activity; metal ion binding

Biological Process: phospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process