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Eotaxin (Ct) (CCL11) Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS194080

Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions. Some G-protein coupled chemokine receptors are also… More details

$560 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Eotaxin (CT) (CCL11), Antibody
Full Product Name
Anti-Eotaxin Antibody
Product Gene Name
anti-CCL11 antibody
Product Synonym Names
Eotaxin (CT); Eotaxin
Host
Rabbit
Form/Format
100 ug IgG in 200 ulPBS, pH 7.4, purified by immunoaffinity chromatography.
Specificity
Eotaxin (CT) [Rabbit antibody to peptide corresponding to aa 83-97 of human eotaxin, an eosinophil chemoattractant.]
This antibody recognizes the monomeric (9 kD) and dimeric (18 kD) forms of human eotaxin
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
Molecular Weight
10,732 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (32612687..32615199). Location: 17q21.1-q21.2
OMIM
601156
3D Structure
ModBase 3D Structure for P51671
Antigen
Peptide corresponding to aa 83-97 of human eotaxin.
Stabilizer
None
Preservatives
0.02% sodium azide.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.

Product Categories/Family for anti-CCL11 antibody

Infectious Disease Antibodies
Applications Tested/Suitable for anti-CCL11 antibody
Immunoblot
Application Notes for anti-CCL11 antibody
Immunoblotting: use at 1:500-1:1,000 dilution.
Positive control: Native and recombinant protein.

Other Notes

Small volumes of anti-CCL11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL11 purchase

MBS194080 is an antibody targeting CCL11. Also known as Anti-Eotaxin Antibody. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL11. It may not necessarily be applicable to this product.

NCBI GI #
2462478
NCBI GeneID
6356
NCBI Accession #
CAB07027.1
UniProt Primary Accession #
P51671
UniProt Secondary Accession #
P50877; Q92490; Q92491
UniProt Related Accession #
P51671; Q6I9T4
NCBI Official Full Name
eotaxin
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 11
NCBI Official Symbol
CCL11
NCBI Official Synonym Symbols
SCYA11; MGC22554
UniProt Protein Name
Eotaxin
UniProt Synonym Protein Names
C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Protein Family
Eotaxin
UniProt Gene Name
CCL11
UniProt Synonym Gene Names
SCYA11
UniProt Entry Name
CCL11_HUMAN
NCBI Protein Information
eotaxin; eotaxin-1; OTTHUMP00000163793; C-C motif chemokine 11; small-inducible cytokine A11; eosinophil chemotactic protein; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)

NCBI Summary for CCL11

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq]
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UniProt Comments for CCL11

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity

Biological Process: chronic inflammatory response; mast cell chemotaxis; response to virus; actin filament organization; cytoskeleton organization and biogenesis; signal transduction; chemotaxis; protein amino acid phosphorylation; cellular calcium ion homeostasis; regulation of cell shape; positive regulation of angiogenesis; response to radiation; positive regulation of actin filament polymerization; eosinophil chemotaxis; immune response; positive regulation of endothelial cell proliferation; cell adhesion; inflammatory response; positive regulation of cell migration

Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
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Research Articles on CCL11

1. After corticosteroid therapy, the expressions of Eotaxin and Eotaxin-2 in mucosal epithelia of nasal polyps were significantly decreased.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL11 antibody

 Reference Product  PubMed Publications
 CCR3 antibody  >287 publications with CCL11 and CCR3
 CCR5 antibody  >48 publications with CCL11 and CCR5
 CCR2 antibody  >38 publications with CCL11 and CCR2
 DPP4 antibody  >1 publications with CCL11 and DPP4

Pathways associated with anti-CCL11 antibody

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-CCL11 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >553 publications with CCL11 and Inflammation
 Respiratory Tract Diseases Antibodies  >478 publications with CCL11 and Respiratory Tract Diseases
 Hypersensitivity Antibodies  >464 publications with CCL11 and Hypersensitivity
 Asthma Antibodies  >421 publications with CCL11 and Asthma
 Lung Diseases Antibodies  >382 publications with CCL11 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >340 publications with CCL11 and Respiratory Hypersensitivity
 Eosinophilia Antibodies  >286 publications with CCL11 and Eosinophilia
 Pulmonary Eosinophilia Antibodies  >85 publications with CCL11 and Pulmonary Eosinophilia
 Rhinitis Antibodies  >73 publications with CCL11 and Rhinitis
 Bronchial Hyperreactivity Antibodies  >71 publications with CCL11 and Bronchial Hyperreactivity

Organs/Tissues associated with anti-CCL11 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >404 publications with CCL11 and Lung
 Heart Antibodies  >58 publications with CCL11 and Heart
 Intestine Antibodies  >41 publications with CCL11 and Intestine
 Uterus Antibodies  >12 publications with CCL11 and Uterus
 Kidney Antibodies  >9 publications with CCL11 and Kidney
 Stomach Antibodies  >6 publications with CCL11 and Stomach
 Pancreas Antibodies  >5 publications with CCL11 and Pancreas
 Mammary Gland Antibodies  >2 publications with CCL11 and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with CCL11 and Uncharacterized Tissue
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