2 (in) (GFR) Antibody – Rabbit

Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survivial and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphatidylinositol linked protein, NTNR alpha , which is a cell surface receptor for NTN. The cDNAs encoding NTNR alpha from human, rat, chicken, and mouse have been cloned. NTNR alpha has also been referred to as GFR alpha -2, GDNFR beta , Ret ligand 2 (RETL2), and TGF- beta -related neurotrophic factor receptor 2 (TmR2). GFR alpha -2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFR alpha -2, and the Ret PTK form a complex to transmit the NTN signal and to mediate NTN function.

Small volumes of anti-GFR-2 (IN) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS194092 is an antibody targeting GFR-2 (IN). Also known as Anti-GFR alpha -2 Antibody. Host: Rabbit.