Gamma (Nt) (IKK) Antibody – Rabbit

Nuclear factor kappa B (NF- kappa B) is a ubiquitous transcription factor and key mediator of gene expression during immune and inflammatory responses. NF- kappa B activates numerous genes in response to extracellular stimuli, such as IL-1, TNF alpha , and LPS. NF- kappa B is associated with I kappa B in cytoplasm, which inhibits NF- kappa B activity. I kappa B is phos-phorylated by the I kappa B kinase (IKK) complex which contains IKK alpha , IKK beta , and IKK epsilon . A novel molecule in the IKK complex, designated IKK gamma , interacts with IKK beta and is required for the activation of IKK complex and NF- kappa B by LPS, PMA, TNF, and IL-1. IKK gamma also binds to RIP and NIK and mediates TNF-induced NF- kappa B activation.

Small volumes of anti-IKK gamma (NT) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS194105 is an antibody targeting IKK gamma (NT). Host: Rabbit.