2 (C1) (IRAK) Antibody – Rabbit

The pro-inflammatory cytokine IL-1 induces cellular responses through two subunits of its receptor, IL-1 receptor 1 (IL-1R1) and IL-1 receptor accessory protein (IL-1RacP). IL-1 receptorassociated kinase (IRAK) mediates activation of NF- kappa B, a key transcription factor that mediates inflammatory and immune respones. A novel member of the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 associate with the subunits of the IL-1R complex after IL-1 binding and lead to NF- kappa B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPSinduced NF- kappa B activation. Members of the IRAK/Pelle family play a central role in IL-1R and TLR-mediated inflammatory responses to IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.

Small volumes of anti-IRAK-2 (C1) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS194110 is an antibody targeting IRAK-2 (C1). Also known as Anti-IRAK2 (CT) Antibody. Host: Rabbit.