• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

SHPRH Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS194137

A novel gene containing SNF2, PHD-finger, RING-finger, helicase, and linker histone domains termed SHPRH, is a possible candidate for a tumor suppressor gene. These domains are characteristic of several DNA repair proteins, transcription factors, and… More details

$500 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SHPRH, Antibody
Full Product Name
Anti-SHPRH Antibody
Product Gene Name
anti-SHPRH antibody
Product Synonym Names
Anti-SHPRH Antibody; SHPRH
Host
Rabbit
Form/Format
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Specificity
Anti-SHPRH Antibody [This antibody recognizes mouse SHPRH (approx. 185 kDa) which has 90% sequence homology with human and 95% sequence homology with rat.]
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
Molecular Weight
193,079 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (146205943..146285233, complement). Location: 6q24.3
OMIM
608048
3D Structure
ModBase 3D Structure for Q149N8
Immunogen
Synthetic peptide corresponding to aa residues 515-535 (DKTKKQAVGSPRKIEKELRKS) of mouse SHPRH conjugated to KLH at the N-terminus.
Stabilizer
None
Preservatives
None. Available on request.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.

Product Categories/Family for anti-SHPRH antibody

Cancer Research Products
Applications Tested/Suitable for anti-SHPRH antibody
Immunoblot
Application Notes for anti-SHPRH antibody
Immunoblotting : use at 1:250 dilution.
Positive control: Mouse brain lysate.

Product References and Citations for anti-SHPRH antibody

Sood R. et al. (2003) Genomics 82:153-161.

Other Notes

Small volumes of anti-SHPRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SHPRH purchase

MBS194137 is an antibody targeting SHPRH. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SHPRH. It may not necessarily be applicable to this product.

NCBI GI #
109734410
NCBI GeneID
257218
UniProt Primary Accession #
Q149N8
UniProt Secondary Accession #
Q149N9; Q5VV79; Q68DS5; Q7Z5J5; Q8IVE8; Q8IWQ9; Q8N1S8; Q8NBR7
UniProt Related Accession #
Q149N8
NCBI Official Full Name
SHPRH protein
NCBI Official Synonym Full Names
SNF2 histone linker PHD RING helicase
NCBI Official Symbol
SHPRH
NCBI Official Synonym Symbols
FLJ27258; FLJ37625; FLJ45012; FLJ90837; KIAA2023; MGC134886; bA545I5.2
UniProt Protein Name
E3 ubiquitin-protein ligase SHPRH
UniProt Synonym Protein Names
SNF2, histone-linker, PHD and RING finger domain-containing helicase
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
SHPRH
UniProt Synonym Gene Names
KIAA2023
UniProt Entry Name
SHPRH_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase SHPRH; 2610103K11Rik; OTTHUMP00000017363; OTTHUMP00000225216; OTTHUMP00000225224; SNF2, histone-linker, PHD and RING finger domain-containing helicase

NCBI Summary for SHPRH

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM]

UniProt Comments for SHPRH

SHPRH: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 3.6.4.-; EC 3.6.1.-; EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; Helicase; Ligase

Chromosomal Location of Human Ortholog: 6q24.3

Cellular Component: nucleosome; nucleus

Molecular Function: DNA binding; zinc ion binding; ubiquitin-protein ligase activity; helicase activity; ATP binding; ligase activity

Biological Process: nucleosome assembly; protein polyubiquitination; DNA repair
Show more

Research Articles on SHPRH

1. HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SHPRH antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >1 publications with SHPRH and Anemia
 Chromosome Aberrations Antibodies  >1 publications with SHPRH and Chromosome Aberrations
 Nervous System Diseases Antibodies  >1 publications with SHPRH and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >1 publications with SHPRH and Neoplasm Metastasis
 Lung Diseases Antibodies  >1 publications with SHPRH and Lung Diseases
 Neoplasms Antibodies  >1 publications with SHPRH and Neoplasms
 Lung Neoplasms Antibodies  >1 publications with SHPRH and Lung Neoplasms

Organs/Tissues associated with anti-SHPRH antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with SHPRH and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000