Survivin (Nt) (BIRC5) Antibody – Rabbit

Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7

Subunit structure: Monomer or homodimer. Exist as a homodimer in the apo state and as a monomer in the CPC-bound state

By similarity. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity. Chromosome › centromere

By similarity. Cytoplasm › cytoskeleton › spindle

By similarity. Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes

By similarity. UniProtKB O15392

Domain: The BIR repeat is necessary and sufficient for HBXIP binding

Post-translational modification: Ubiquitination is required for centrosomal targeting

By similarity.In vitro phosphorylation at Thr-117 by AURKB/STK12 prevents interaction with INCENP and localization to mitotic chromosomes

Sequence similarities: Belongs to the IAP family.Contains 1 BIR repeat.