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P8 (Ct) (NUPR1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS194322

MBS194322 is an antibody targeting NUPR1. Also known as p8 (CT) Polyclonal Antibody. Host: Rabbit. More details

$475 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
p8 (CT) (NUPR1), Polyclonal Antibody
Full Product Name
p8 (CT) Polyclonal Antibody
Product Gene Name
anti-NUPR1 antibody
Product Synonym Names
p8 (CT); p8
Clonality
Polyclonal
Host
Rabbit
Form/Format
100 ug affinity-purified antibody in phosphate-buffered saline, pH 7.4.
Specificity
p8 (CT) [This rabbit antibody recognizes the C-terminus of human p8 protein.]
This antibody recognizes human p8 protein, a nuclear protein with potent mitogenic activity that is expressed in the pancreas during acute pancreatitis. Cells that express p8 grow more rapidly than non-p8 expessing cells.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
Molecular Weight
8,873 Da
3D Structure
ModBase 3D Structure for O60356
Antigen
Peptide corresponding to the C-terminus of human p8 protein.
Stabilizer
None
Preservatives
0.02% sodium azide
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.

Product Categories/Family for anti-NUPR1 antibody

Growth Factors/Cytokines/Receptor Antibodies
Applications Tested/Suitable for anti-NUPR1 antibody
Immunoblot
Application Notes for anti-NUPR1 antibody
Immunoblotting: use at 1:500-1:1,000 dilution. In immunoblots, a band of approximately 8 kD is detected.

Other Notes

Small volumes of anti-NUPR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NUPR1. It may not necessarily be applicable to this product.

NCBI GI #
49457284
NCBI GeneID
26471
NCBI Accession #
CAG46941.1
UniProt Primary Accession #
O60356
UniProt Secondary Accession #
O60357; Q6FGG3
UniProt Related Accession #
O60356; Q6FGG3
NCBI Official Full Name
P8
NCBI Official Synonym Full Names
nuclear protein, transcriptional regulator, 1
NCBI Official Symbol
NUPR1
NCBI Official Synonym Symbols
P8; COM1; NUPR1
UniProt Protein Name
Nuclear protein 1
UniProt Synonym Protein Names
Candidate of metastasis 1; Protein p8
Protein Family
Nuclear protein
UniProt Gene Name
NUPR1
UniProt Synonym Gene Names
COM1
UniProt Entry Name
NUPR1_HUMAN
NCBI Protein Information
p8 protein; nuclear protein 1; candidate of metastasis 1

UniProt Comments for NUPR1

NUPR1: Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. May contribute to the metastatic phenotype. Belongs to the NUPR family.

Protein type: Cell cycle regulation; Apoptosis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; nucleus

Molecular Function: DNA binding; chromatin binding

Biological Process: transcription, DNA-dependent; positive regulation of apoptosis; response to toxin; male gonad development; negative regulation of cell cycle; protein amino acid acetylation; regulation of transcription, DNA-dependent; negative regulation of fibroblast proliferation; positive regulation of protein modification process; protein complex assembly; cell growth; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; acute inflammatory response
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Research Articles on NUPR1

1. nuclear protein 1 (NUPR1) has a role in cancer progression [review]
2. Upregulation of NUPR1 is associated with aggressive breast cancer.
3. These results identify an unexpectedly broad involvement for p8 in key cellular events linked to cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloproteases production, both of which occur in heart failure.
4. The fate of Com-1 can be dually regulated by oestrogen and ubiquitin pathway
5. Antiapoptotic response of cells requires expression of both p8 and ProTalpha.
6. CCM1 gene mutation of 1292delAT may contribute to cerebral cavernous malformations.
7. SYT-SSX1 fusion protein directly down-regulated the expression of COM1, a regulator of cell proliferation.
8. clinical and cell line specific expression identified in experimental central nervous system metastases
9. The results suggest that p8 growth stage-dependent localization is regulated by acetylation, that p8 is not free within the cell but forming part of a complex and that it may exert a role in both subcellular localizations.
10. the anti-apoptotic effect previously attributed separately to p8 and prothymosin alpha is in fact borne by the p8/ProTalpha complex, the two proteins being individually inactive
11. p8 expression plays an important role in the progression of medullary thyroid carcinoma, but does not have an anti-apoptotic function.
12. The knock-down of p8 expression results in a strong inhibition of Jab1 activity.
13. Com-1/p8 is a potential tumour suppressor in human prostate cancer.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NUPR1 antibody

 Reference Product  PubMed Publications
 EP300 antibody  >3 publications with NUPR1 and EP300
 PAXIP1 antibody  >1 publications with NUPR1 and PAXIP1

Pathways associated with anti-NUPR1 antibody

 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-NUPR1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with NUPR1 and Neoplasms
 Breast Neoplasms Antibodies  >6 publications with NUPR1 and Breast Neoplasms
 Male Urogenital Diseases Antibodies  >5 publications with NUPR1 and Male Urogenital Diseases
 Necrosis Antibodies  >5 publications with NUPR1 and Necrosis
 Neoplasm Metastasis Antibodies  >4 publications with NUPR1 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >4 publications with NUPR1 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >4 publications with NUPR1 and Inflammation
 Skin Diseases Antibodies  >3 publications with NUPR1 and Skin Diseases
 Female Urogenital Diseases Antibodies  >3 publications with NUPR1 and Female Urogenital Diseases
 Drug Toxicity Antibodies  >2 publications with NUPR1 and Drug Toxicity

Organs/Tissues associated with anti-NUPR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >11 publications with NUPR1 and Pancreas
 Brain Antibodies  >5 publications with NUPR1 and Brain
 Liver Antibodies  >5 publications with NUPR1 and Liver
 Lung Antibodies  >4 publications with NUPR1 and Lung
 Nerve Antibodies  >3 publications with NUPR1 and Nerve
 Muscle Antibodies  >3 publications with NUPR1 and Muscle
 Kidney Antibodies  >3 publications with NUPR1 and Kidney
 Bone Antibodies  >2 publications with NUPR1 and Bone
 Heart Antibodies  >2 publications with NUPR1 and Heart
 Eye Antibodies  >2 publications with NUPR1 and Eye
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