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Ceramide Kinase (CERK) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS194401

Ceramide kinase (CERK), which phosphorylates ceramide to produce ceramide 1-phosphate (C1P), was first described as a Ca+2-stimulated lipid kinase that copurified with brain synaptic vesicles. CERK activity has been reported in HL60 cells, mast cells, and… More details

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Product Overview

Online Datasheet in PDF
Product Name
Ceramide Kinase (CERK), Polyclonal Antibody
Full Product Name
Rabbit polyclonal antibody recognizes human Ceramide Kinase
Product Gene Name
anti-CERK antibody
Product Synonym Names
Ceramide Kinase
Clonality
Polyclonal
Host
Rabbit
Form/Format
50ug peptide immunogen affinity purified antibody in PBS containing 0.1% sodium azide.
Specificity
Ceramide Kinase [Rabbit polyclonal antibody recognizes human Ceramide Kinase]
This antibody recognizes the N-terminal extracellular domain of human CERK.
Preparation and Storage
This antibody is stable at 4 degree C (short-term) and -70 degree C (long-term).
Molecular Weight
21,667 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (47080307..47134152, complement). Location: 22q13.31
3D Structure
ModBase 3D Structure for Q6I9Z0
Antigen
Synthetic peptide conjugated to KLH.
Preservatives
0.1% sodium azide
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.

Product Categories/Family for anti-CERK antibody

Enzyme and Enzyme Inhibitor Antibodies
Applications Tested/Suitable for anti-CERK antibody
Immunohistochemistry
Application Notes for anti-CERK antibody
Immunohistochemistry: Use at 20ug/ml.

Other Notes

Small volumes of anti-CERK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CERK purchase

MBS194401 is an antibody targeting CERK. Also known as Rabbit polyclonal antibody recognizes human Ceramide Kinase. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CERK. It may not necessarily be applicable to this product.

NCBI GI #
20336726
NCBI GeneID
64781
NCBI Accession #
NP_073603.2
UniProt Primary Accession #
Q6I9Z0
UniProt Related Accession #
Q6I9Z0; Q6NX59; Q8TCT0; Q9H5N7
GenBank Nucleotide #
NM_022766.5
NCBI Official Full Name
ceramide kinase
NCBI Official Synonym Full Names
ceramide kinase
NCBI Official Symbol
CERK
NCBI Official Synonym Symbols
LK4; hCERK; FLJ21430; FLJ23239; KIAA1646; MGC131878; dA59H18.2; dA59H18.3; DKFZp434E0211
UniProt Protein Name
CERK protein
Protein Family
Ceramide kinase
UniProt Gene Name
CERK
UniProt Entry Name
Q6I9Z0_HUMAN
NCBI Protein Information
ceramide kinase; lipid kinase 4; lipid kinase LK4; OTTHUMP00000197262; acylsphingosine kinase

NCBI Summary for CERK

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM]

UniProt Comments for CERK

CERK: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Protein type: Lipid Metabolism - sphingolipid; Kinase, lipid; EC 2.7.1.138

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: mitochondrion; plasma membrane; integral to membrane

Molecular Function: ceramide kinase activity; magnesium ion binding; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity

Biological Process: sphingolipid metabolic process; protein kinase C activation; glycosphingolipid metabolic process; ceramide metabolic process; lipid phosphorylation; transmembrane transport
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Research Articles on CERK

1. We have identified a differential role for ceramide kinase in mast-cell activation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CERK antibody

 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram

Diseases associated with anti-CERK antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with CERK and Neoplasms
 Lung Diseases Antibodies  >3 publications with CERK and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with CERK and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with CERK and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with CERK and Liver Neoplasms
 Hypertension Antibodies  >1 publications with CERK and Hypertension
 Skin Diseases Antibodies  >1 publications with CERK and Skin Diseases
 Kidney Diseases Antibodies  >1 publications with CERK and Kidney Diseases

Organs/Tissues associated with anti-CERK antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with CERK and Blood
 Bone Antibodies  >4 publications with CERK and Bone
 Vascular Antibodies  >4 publications with CERK and Vascular
 Bone Marrow Antibodies  >3 publications with CERK and Bone Marrow
 Liver Antibodies  >3 publications with CERK and Liver
 Spleen Antibodies  >3 publications with CERK and Spleen
 Kidney Antibodies  >2 publications with CERK and Kidney
 Muscle Antibodies  >2 publications with CERK and Muscle
 Brain Antibodies  >2 publications with CERK and Brain
 Skin Antibodies  >1 publications with CERK and Skin
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