• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Toll-Like Receptor 3 (TLR3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS194448

TLR3 is a 904 aa protein with 24 N-terminal leucine-rich repeat motifs (LRRs) and a molecular weight of 97 kDa. TLR3 is most closely related to TLR5, TLR7, and TLR8, each with 26% overall sequence identity. In vivo, two different sized transcripts for TLR3… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
Toll-like Receptor 3 (TLR3), Polyclonal Antibody
Full Product Name
Toll-like Receptor 3 (TLR3) Polyclonal Antibody
Product Gene Name
anti-Tlr3 antibody
Product Synonym Names
Toll-like Receptor 3 (TLR3)
Clonality
Polyclonal
Host
Rabbit
Form/Format
50 ug purified by antigen affinity chromatography in PBS containing 0.02% sodium azide.
Specificity
Toll-like Receptor 3 (TLR3) [Rabbit polyclonal antibody recognizes human and mouse TLR3]
This antibody recognizes human and mouse TLR3.
Preparation and Storage
Store at 4 degree C. Avoid freezing.
Molecular Weight
103,175 Da
Chromosome Location
Chromosome: 16; NC_005115.2 (50112910..50126371). Location: 16q11
3D Structure
ModBase 3D Structure for Q7TNI8
Antigen
Synthetic peptide corresponding to 15 amino acids near the N-terminus of human TLR3.
Preservatives
0.02% sodium azide
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.

Product Categories/Family for anti-Tlr3 antibody

Neuroscience and Signal Transduction Antibodies
Applications Tested/Suitable for anti-Tlr3 antibody
Western Blot, Immunohistochemistry
Application Notes for anti-Tlr3 antibody
Western Blotting: use at 1-2ug/ml. A band of approximately 97 kDa is detected.
Immunohistochemistry: formalin-fixed, paraffin-embedded tissues, use at 5ug/ml.

Immunohistochemistry of anti-Tlr3 antibody

Rabbit Anti-TLR3 Polyclonal Antibody – Cat# MBS194448

Other Notes

Small volumes of anti-Tlr3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tlr3 purchase

MBS194448 is an antibody targeting Tlr3. Also known as Toll-like Receptor 3 (TLR3) Polyclonal Antibody. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Tlr3. It may not necessarily be applicable to this product.

NCBI GI #
38454316
NCBI GeneID
364594
NCBI Accession #
NP_942086.1
UniProt Primary Accession #
Q7TNI8
UniProt Related Accession #
Q7TNI8; Q80Z88
GenBank Nucleotide #
NM_198791.1
NCBI Official Full Name
toll-like receptor 3
NCBI Official Synonym Full Names
toll-like receptor 3
NCBI Official Symbol
Tlr3
NCBI Official Synonym Symbols
Tlr3
UniProt Protein Name
Toll-like receptor 3
Protein Family
Toll-like receptor
UniProt Gene Name
Tlr3
UniProt Entry Name
Q7TNI8_RAT
NCBI Protein Information
toll-like receptor 3

NCBI Summary for Tlr3

human homolog induces activation of NF-kappaB; mouse homolog plays a role in the production of inflammatory cytokines [RGD]

UniProt Comments for Tlr3

TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: cell surface; lysosomal membrane; cytoplasm; integral to membrane; intracellular

Molecular Function: identical protein binding; transmembrane receptor activity; double-stranded RNA binding; receptor activity

Biological Process: positive regulation of interleukin-12 production; positive regulation of apoptosis; microglial cell activation; positive regulation of JNK cascade; defense response; positive regulation of interferon-alpha biosynthetic process; positive regulation of NF-kappaB import into nucleus; toll-like receptor 3 signaling pathway; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; positive regulation of interferon type I production; defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; response to virus; male gonad development; response to dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of chemokine biosynthetic process; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; I-kappaB phosphorylation; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process; microglial cell activation during immune response
Show more

Research Articles on Tlr3

1. Cellular RNA released from necrotic cells can act as an endogenous TLR3 ligand to induce clusterin expression in vitro in vascular smooth muscle cells and in vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Tlr3 antibody

 Products by Pathway  Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immunity Signaling Pathway antibodies  Innate Immunity Signaling Pathway Diagram
 TRAF6 Mediated Induction Of Proinflammatory Cytokines Pathway antibodies  TRAF6 Mediated Induction Of Proinflammatory Cytokines Pathway Diagram
 Toll Like Receptor 3 (TLR3) Cascade Pathway antibodies  Toll Like Receptor 3 (TLR3) Cascade Pathway Diagram
 Toll Receptor Cascades Pathway antibodies  Toll Receptor Cascades Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram

Diseases associated with anti-Tlr3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >306 publications with Tlr3 and Inflammation
 Necrosis Antibodies  >217 publications with Tlr3 and Necrosis
 Neoplasms Antibodies  >101 publications with Tlr3 and Neoplasms
 Hepatitis Antibodies  >69 publications with Tlr3 and Hepatitis
 Nervous System Diseases Antibodies  >68 publications with Tlr3 and Nervous System Diseases
 Lung Diseases Antibodies  >49 publications with Tlr3 and Lung Diseases
 Asthma Antibodies  >44 publications with Tlr3 and Asthma
 Skin Diseases Antibodies  >42 publications with Tlr3 and Skin Diseases
 Carcinoma Antibodies  >40 publications with Tlr3 and Carcinoma
 Kidney Diseases Antibodies  >37 publications with Tlr3 and Kidney Diseases

Organs/Tissues associated with anti-Tlr3 antibody

 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >3 publications with Tlr3 and Ovary
 Dorsal Root Ganglion Antibodies  >2 publications with Tlr3 and Dorsal Root Ganglion
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000