Keratinocyte Growth Factor (Rhukgf) (FGF7) Active Protein

Name: FGF7 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS197014
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS197014

Recombinant Human KGF produced in E. coli is a single, non-glycosylated, polypeptide chain containing 164 amino acids with a molecular mass of 18,995 daltons. This product has full biological activity. More details

$265 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Keratinocyte Growth Factor (rHuKGF) (FGF7), Active Protein

Full Product Name

Recombinant Human Keratinocyte Growth Factor

Product Gene Name

FGF7 active protein

Product Synonym Names

Recombinant Human Keratinocyte Growth Factor (rHuKGF)

Host

E Coli

Form/Format

Sterile filtered, lyophilized.

Purity/Purification

Greater than 97% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain.
Purification: Chromatographic

Specificity

Recombinant Human Keratinocyte Growth Factor (rHuKGF)

Preparation and Storage

Lyophilized product is stable at room temperature for 3 weeks. Store lyophilized product desiccated at -20 degree C. Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at -20 degree C. For long-term storage add either HSA or BSA to 0.1%. Avoid repeated freeze-thaw cycles.

Molecular Weight

22,509 Da

Chromosome Location

Chromosome: 15; NC_000015.9 (49715375..49779523). Location: 15q21.2

OMIM

148180

3D Structure

ModBase 3D Structure for P21781

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Dimers/Aggregates

<1% by SDSPAGE

Biological Activity

Fully biologically active compared to reference standards. Specific Activity is 105 Units/mg.

Endotoxin Level

<0.1 ng/ug

Protein Content

Determined spectrophotometrically at 280nm (extinction coefficient 0.9) and by RPHPLC analysis against a calibrated standard.

Solubility

Reconstitute the lyophilized product in sterile water not less than 100 ug/ml.

Stabilizer

None

Preservatives

None

Product Categories/Family for FGF7 active protein

Recombinant Proteins

Other Notes

Small volumes of FGF7 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF7 purchase

MBS197014 is an active protein targeting FGF7. Also known as Recombinant Human Keratinocyte Growth Factor. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF7. It may not necessarily be applicable to this product.

NCBI GI #

4503705

NCBI GeneID

2252

NCBI Accession #

NP_002000.1

UniProt Primary Accession #

P21781

UniProt Related Accession #

P21781; Q6FGV5; Q6RK68; Q96FG5

GenBank Nucleotide #

NM_002009.3

NCBI Official Full Name

keratinocyte growth factor

NCBI Official Synonym Full Names

fibroblast growth factor 7

NCBI Official Symbol

FGF7

NCBI Official Synonym Symbols

KGF; HBGF-7

UniProt Protein Name

Keratinocyte growth factor

UniProt Synonym Protein Names

Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7

Protein Family

Fibroblast growth factor

UniProt Gene Name

FGF7

UniProt Synonym Gene Names

KGF

UniProt Entry Name

FGF7_HUMAN

NCBI Protein Information

keratinocyte growth factor; FGF-7; OTTHUMP00000162252; heparin-binding growth factor 7

NCBI Summary for FGF7

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq]

UniProt Comments for FGF7

FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: Golgi apparatus; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; chemoattractant activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; epidermis development; hair follicle morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; mesenchymal cell proliferation; signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; actin cytoskeleton reorganization; response to wounding; insulin receptor signaling pathway; innate immune response; positive regulation of epithelial cell proliferation

Research Articles on FGF7

1. Carcinoma-associated fibroblasts promotes the proliferation of a lingual carcinoma cell line by secreting keratinocyte growth factor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF7 active protein

Reference Product	PubMed Publications
FGFR2 active protein	>234 publications with FGF7 and FGFR2
FGFR1 active protein	>56 publications with FGF7 and FGFR1
FGFR3 active protein	>25 publications with FGF7 and FGFR3
FGFR4 active protein	>17 publications with FGF7 and FGFR4
COL1A1 active protein	>1 publications with FGF7 and COL1A1

Pathways associated with FGF7 active protein

Products by Pathway	Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
FGFR Ligand Binding And Activation Pathway antibodies	FGFR Ligand Binding And Activation Pathway Diagram
FGFR2 Ligand Binding And Activation Pathway antibodies	FGFR2 Ligand Binding And Activation Pathway Diagram
FGFR2b Ligand Binding And Activation Pathway antibodies	FGFR2b Ligand Binding And Activation Pathway Diagram
FRS2-mediated Cascade Pathway antibodies	FRS2-mediated Cascade Pathway Diagram
Glypican 3 Network Pathway antibodies	Glypican 3 Network Pathway Diagram
IRS-mediated Signalling Pathway antibodies	IRS-mediated Signalling Pathway Diagram
IRS-related Events Pathway antibodies	IRS-related Events Pathway Diagram
Insulin Receptor Signalling Cascade Pathway antibodies	Insulin Receptor Signalling Cascade Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram

Diseases associated with FGF7 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>159 publications with FGF7 and Neoplasms
Carcinoma Antibodies	>68 publications with FGF7 and Carcinoma
Lung Injury Antibodies	>60 publications with FGF7 and Lung Injury
Respiratory Tract Diseases Antibodies	>58 publications with FGF7 and Respiratory Tract Diseases
Lung Diseases Antibodies	>57 publications with FGF7 and Lung Diseases
Skin Diseases Antibodies	>49 publications with FGF7 and Skin Diseases
Inflammation Antibodies	>44 publications with FGF7 and Inflammation
Fibrosis Antibodies	>33 publications with FGF7 and Fibrosis
Intestinal Diseases Antibodies	>32 publications with FGF7 and Intestinal Diseases
Mucositis Antibodies	>31 publications with FGF7 and Mucositis

Organs/Tissues associated with FGF7 active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>164 publications with FGF7 and Lung
Skin Antibodies	>151 publications with FGF7 and Skin
Embryonic Tissue Antibodies	>104 publications with FGF7 and Embryonic Tissue
Prostate Antibodies	>70 publications with FGF7 and Prostate
Intestine Antibodies	>67 publications with FGF7 and Intestine
Bone Antibodies	>61 publications with FGF7 and Bone
Vascular Antibodies	>46 publications with FGF7 and Vascular
Kidney Antibodies	>37 publications with FGF7 and Kidney
Muscle Antibodies	>37 publications with FGF7 and Muscle
Eye Antibodies	>30 publications with FGF7 and Eye