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Hsph1 (Hsp105) (HspH1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS197027

HspH1 is a member of the mammalian Hsp105/110 family, a subgroup of the Hsp70 family. Two isoforms of HspH1, alpha and beta, have been identified. HspH1 associates with Hsp70/Hsc70 as complexes and negatively regulates the chaperone activity of Hsp70/Hsc70 in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HspH1 (Hsp105), Recombinant Protein
Full Product Name
Recombinant Human HspH1 (Hsp105)
Product Gene Name
HspH1 recombinant protein
Sequence
MRGSHHHHHH GMASMTGGQ MGRDLYDDDD KDRWGSMSVV GLDVGSQSCY IAVARAGGIE TIANEFSDRC TPSVISFGSK NRTIGVAAKN QQITHANNTV SNFKRFHGRA FNDPFIQKEK ENLSYDLVPL KNGGVGIKVM YMGEEHLFSV EQITAMLLTK LKETAENSLK KPVTDCVISV PSFFTDAERR SVLDAAQIVG LNCLRLMNDM TAVALNYGIY KQDLPSLDEK PRIVVFVDMG HSAFQVSACA FNKGKLKVLG TAFDPFLGGK NFDEKLVEHF CAEFKTKYKL DAKSKIRALL RLYQECEKLK KLMSSNSTDL PLNIECFMND KDVSGKMNRS QFEELCAELL QKIEVPLYSL LEQTHLKVED VSAVEIVGGA TRIPAVKERI AKFFGKDIST TLNADEA VAR GCALQCAILS PAFKVREFSV TDAVPFPISL IWNHDSEDTE GVHEVFSRNH AAPFSKVLTF LRRGPFELEA FYSDPQGVPY PEAKIGRFVV QNVSAQKDGE KSRVKVKVRV NTHGIFTIST ASMVEKVPTE ENEMSSEADM ECLNQRPPEN PDTDKNVQQD NSEAGTQPQV QTDAQQTSQS PPSPELTSEE NKIPDADKAN EKKVDQPPEA KKPKIKVVNV ELPIEANLVW QLGKDLLNMY IETEGKMIMQ DKLEKERNDA KNAVEEYVYE FRDKLCGPYE KFICEQDHQN FLRLLTETED WLYEEGEDQA KQAYVDKLEE LMKIGTPVKV RFQEAEERPK MFEELGQRLQ HYAKIAADFR NKDEKYNHID ESEMKKVEKS VNEVMEWMNN VMNAQAKKSL DQDPVVRAQE IKTKIKELNN TCEPVVTQPK PKIESPKLER TPNGPNIDKK EEDLEDKNNF GAEPPHQNGE CYPNEKNSVN MDLD.
Host
E Coli
Form/Format
Sterile-filtered colorless solution in 20mM Tris-HCl, pH 8.0, and 50mM NaCl. Purified by proprietary chromatographic techniques.
Purity/Purification
Greater than 90% as determined by SDS-PAGE and RP-HPLC.
Specificity
Human HspH1 (Hsp105)
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store at or below -20 degree C for longer periods of time. Addition of a carrier protein (such as 0.1% HAS or BSA) is recommended for long-term storage.
Molecular Weight
96,865 Da
Chromosome Location
Chromosome: 13; NC_000013.10 (31710762..31736117, complement). Location: 13q12.3
OMIM
610703
3D Structure
ModBase 3D Structure for Q92598

Other Notes

Small volumes of HspH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HspH1 purchase

MBS197027 is a recombinant protein targeting HspH1. Also known as Recombinant Human HspH1 (Hsp105). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HspH1. It may not necessarily be applicable to this product.

NCBI GI #
42544159
NCBI GeneID
10808
NCBI Accession #
NP_006635.2
UniProt Primary Accession #
Q92598
UniProt Secondary Accession #
O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q9UPC4
UniProt Related Accession #
Q92598
GenBank Nucleotide #
NM_006644.2
NCBI Official Full Name
heat shock protein 105 kDa
NCBI Official Synonym Full Names
heat shock 105kDa/110kDa protein 1
NCBI Official Symbol
HSPH1
NCBI Official Synonym Symbols
HSP105; HSP105A; HSP105B; KIAA0201; NY-CO-25; DKFZp686M05240
UniProt Protein Name
Heat shock protein 105 kDa
UniProt Synonym Protein Names
Antigen NY-CO-25; Heat shock 110 kDa protein
Protein Family
Heat shock protein
UniProt Gene Name
HSPH1
UniProt Synonym Gene Names
HSP105; HSP110; KIAA0201
UniProt Entry Name
HS105_HUMAN
NCBI Protein Information
heat shock protein 105 kDa; antigen NY-CO-25; OTTHUMP00000018208; OTTHUMP00000018209; OTTHUMP00000018210; heat shock 105kD beta; heat shock 105kD alpha; heat shock 110 kDa protein; heat shock 105kDa protein 1

UniProt Comments for HspH1

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function: protein binding; ATP binding; alpha-tubulin binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein
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Research Articles on HspH1

1. Hsp105alpha and Hsp105beta suppressed the expanded polyQ tract-induced protein aggregation and apoptosis through the induction of Hsp70.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HspH1 recombinant protein

 Reference Product  PubMed Publications
 HSPA8 recombinant protein  >3 publications with HspH1 and HSPA8

Pathways associated with HspH1 recombinant protein

 Products by Pathway  Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with HspH1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11 publications with HspH1 and Neoplasms
 Adenocarcinoma Antibodies  >4 publications with HspH1 and Adenocarcinoma
 Carcinoma Antibodies  >4 publications with HspH1 and Carcinoma
 Skin Neoplasms Antibodies  >3 publications with HspH1 and Skin Neoplasms
 Lymphoma Antibodies  >2 publications with HspH1 and Lymphoma
 Neurodegenerative Diseases Antibodies  >2 publications with HspH1 and Neurodegenerative Diseases
 Inflammation Antibodies  >2 publications with HspH1 and Inflammation
 Melanoma Antibodies  >2 publications with HspH1 and Melanoma
 Leukemia Antibodies  >2 publications with HspH1 and Leukemia
 Carcinoma, Squamous Cell Antibodies  >2 publications with HspH1 and Carcinoma, Squamous Cell

Organs/Tissues associated with HspH1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with HspH1 and Brain
 Skin Antibodies  >5 publications with HspH1 and Skin
 Blood Antibodies  >4 publications with HspH1 and Blood
 Testis Antibodies  >3 publications with HspH1 and Testis
 Vascular Antibodies  >2 publications with HspH1 and Vascular
 Intestine Antibodies  >2 publications with HspH1 and Intestine
 Lymph Antibodies  >2 publications with HspH1 and Lymph
 Lymph Node Antibodies  >2 publications with HspH1 and Lymph Node
 Pancreas Antibodies  >1 publications with HspH1 and Pancreas
 Thyroid Antibodies  >1 publications with HspH1 and Thyroid
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