Human HspA5 Recombinant Protein – Cat# MBS197043

Hspa5 (Hsp70 Protein 5) (HspA5) Human Recombinant Protein

Name: HspA5 Recombinant Protein; Hspa5 (Hsp70 Protein 5); Human; MyBioSource
Brand: MyBioSource
SKU: MBS197043
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS197043

HspA5, a member of the Hsp70 family, plays a role in folding and assembling of proteins in the endoplasmic reticulum by monitoring protein transport through the cell. HspA5 is a stress response protein that is induced by conditions that adversely affect… More details

$265 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HspA5 (Hsp70 protein 5), Recombinant Protein

Full Product Name

Recombinant Human HspA5 (Hsp70 protein 5)

Product Gene Name

HspA5 recombinant protein

Sequence

EEDKKEDVG TVVGIDLGTT YSCVGVFKNG RVEIIANDQG NRITPSYVAF TPEGERLIGD AAKNQLTSNP ENTVFDAKRL IGRTWNDPSV QQDIKFLPFK VVEKKTKPYI QVDIGGGQTK TFAPEEISAM VLTKMKETAE AYLGKKVTHA VVTVPAYFND AQRQATKDAG TIAGLNVMRI INEPTAAAIA YGLDKREGEK NILVFDLGGG TFDVSLLTID NGVFEVVATN GDTHLGGEDF DQRVMEHFIK LYKKKTGKDV RKDNRAVQKL RREVEKAKRA LSSQHQARIE IESFYEGEDF SETLTRAKFE ELNMDLFRST MKPVQKVLED SDLKKSDIDE IVLVGGSTRI PKIQQLVKEF FNGKEPSRGI NPDEAVAYGA AVQAGVLSGD QDTGDLVLLD VCPLTLGIET VGGVMTKLIP RNTVVPTKKS QIFSTASDNQ PTVTIKVYEG ERPLTKDNHL LGTFDLTGIP PAPRGVPQIE VTFEIDVNGI LRVTAEDKGT GNKNKITITN DQNRLTPEEI ERMVNDAEKF AEEDKKLKER IDTRNELESY AYSLKNQIGD KEKLGGKLSS EDKETMEKAV EEKIEWLESH QDADIEDFKA KKKELEEIVQ PIISKLYGSA GPPPTGEEDT AELEHHH HHH

Host

E Coli

Form/Format

Sterile-filtered colorless solution in 20mM Tris-Hcl, pH 8.0 and 10% glycerol. Purified by proprietary chromatographic techniques.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Specificity

Human HspA5 (Hsp70 protein 5)

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store at or below -20 degree C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA is recommended for long-term storage.

Molecular Weight

72,333 Da

Chromosome Location

Chromosome: 9; NC_000009.11 (127997127..128003661, complement). Location: 9q33.3

OMIM

138120

3D Structure

ModBase 3D Structure for P11021

Other Notes

Small volumes of HspA5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HspA5 purchase

MBS197043 is a recombinant protein targeting HspA5. Also known as Recombinant Human HspA5 (Hsp70 protein 5). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HspA5. It may not necessarily be applicable to this product.

NCBI GI #

16507237

NCBI GeneID

3309

NCBI Accession #

NP_005338.1

UniProt Primary Accession #

P11021

UniProt Secondary Accession #

Q2EF78; Q9NPF1; Q9UK02; B0QZ61

UniProt Related Accession #

P11021

GenBank Nucleotide #

NM_005347.4

NCBI Official Full Name

78 kDa glucose-regulated protein

NCBI Official Synonym Full Names

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

NCBI Official Symbol

HSPA5

NCBI Official Synonym Symbols

BIP; MIF2; GRP78; FLJ26106

UniProt Protein Name

78 kDa glucose-regulated protein

UniProt Synonym Protein Names

Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein

UniProt Gene Name

HSPA5

UniProt Synonym Gene Names

GRP78

UniProt Entry Name

GRP78_HUMAN

NCBI Protein Information

78 kDa glucose-regulated protein; OTTHUMP00000022124; immunoglobulin heavy chain-binding protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78

NCBI Summary for HspA5

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.

UniProt Comments for HspA5

GRP78: a member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. Plays a central role in regulating the unfolded protein response (UPR), and is an obligatory component of autophagy in mammalian cells. May play an important role in cellular adaptation and oncogenic survival. One of the client proteins of GRP78 is protein double-stranded RNA-activated protein-like endoplasmic reticulum kinase (PERK). Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: signalosome; endoplasmic reticulum membrane; cell surface; smooth endoplasmic reticulum; focal adhesion; mitochondrion; endoplasmic reticulum lumen; endoplasmic reticulum; ER-Golgi intermediate compartment; membrane; melanosome; plasma membrane; integral to endoplasmic reticulum membrane; midbody; nucleus

Molecular Function: protein domain specific binding; protein binding; enzyme binding; ubiquitin protein ligase binding; chaperone binding; unfolded protein binding; ATPase activity; ribosome binding; misfolded protein binding; calcium ion binding; glycoprotein binding; ATP binding

Biological Process: platelet activation; ER-associated protein catabolic process; cerebellum structural organization; unfolded protein response; cerebellar Purkinje cell layer development; cellular response to glucose starvation; platelet degranulation; cellular protein metabolic process; substantia nigra development; unfolded protein response, activation of signaling protein activity; positive regulation of protein ubiquitination; negative regulation of transforming growth factor beta receptor signaling pathway; blood coagulation; ER overload response; positive regulation of cell migration; negative regulation of apoptosis

Research Articles on HspA5

1. Knockdown of GRP78 expression by siRNA did not effect viral RNA replication, but did impair mature viral production.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HspA5 recombinant protein

Reference Product	PubMed Publications
SIL1 recombinant protein	>3 publications with HspA5 and SIL1
ERP29 recombinant protein	>1 publications with HspA5 and ERP29
ERN1 recombinant protein	>1 publications with HspA5 and ERN1
EIF2AK3 recombinant protein	>1 publications with HspA5 and EIF2AK3

Pathways associated with HspA5 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Chaperones By ATF6-alpha Pathway antibodies	Activation Of Chaperones By ATF6-alpha Pathway Diagram
Activation Of Chaperones By IRE1alpha Pathway antibodies	Activation Of Chaperones By IRE1alpha Pathway Diagram
Adaptive Immunity Signaling Pathway antibodies	Adaptive Immunity Signaling Pathway Diagram
Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies	Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Diabetes Pathways antibodies	Diabetes Pathways Diagram
Formation Of Platelet Plug Pathway antibodies	Formation Of Platelet Plug Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with HspA5 recombinant protein

Disease Name	Pubmed Publications
Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules Antibodies	>2426 publications with HspA5 and Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules
Death Antibodies	>51 publications with HspA5 and Death
Drug Toxicity Antibodies	>24 publications with HspA5 and Drug Toxicity
Metabolic Diseases Antibodies	>18 publications with HspA5 and Metabolic Diseases
Neoplasms Antibodies	>16 publications with HspA5 and Neoplasms
Neurodegenerative Diseases Antibodies	>15 publications with HspA5 and Neurodegenerative Diseases
Brain Ischemia Antibodies	>13 publications with HspA5 and Brain Ischemia
Urologic Diseases Antibodies	>12 publications with HspA5 and Urologic Diseases
Inflammation Antibodies	>10 publications with HspA5 and Inflammation
Necrosis Antibodies	>9 publications with HspA5 and Necrosis

Organs/Tissues associated with HspA5 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>45 publications with HspA5 and Brain
Muscle Antibodies	>26 publications with HspA5 and Muscle
Kidney Antibodies	>20 publications with HspA5 and Kidney
Heart Antibodies	>18 publications with HspA5 and Heart
Liver Antibodies	>15 publications with HspA5 and Liver
Blood Antibodies	>15 publications with HspA5 and Blood
Testis Antibodies	>10 publications with HspA5 and Testis
Nerve Antibodies	>10 publications with HspA5 and Nerve
Vascular Antibodies	>10 publications with HspA5 and Vascular
Pancreas Antibodies	>9 publications with HspA5 and Pancreas