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CCL19 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS197063

CCL19 (also known as Macrophage Inflammatory Protein-3β, MIP-3β, and EBI1 ligand chemokine, ELC) directs chemotaxis of dendritic cells and certain B- and T-lymphocytes, but not monocytes or granulocytes. It is constitutively expressed in thymus and lymph… More details

$200 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCL19, Active Protein
Full Product Name
Recombinant CCL19 (MIP-3β)
Product Gene Name
CCL19 active protein
Product Synonym Gene Name
MIP-3beta
Product Synonym Names
Recombinant Human CCL19
Sequence
GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
Host
E. coli
Form/Format
Sterile Filtered White Lyophilized Powder
Purity/Purification
>97% by SDS-PAGE
Preparation and Storage
12 months from date of receipt, -20°C to -70°C, as supplied.
1 month, 2°C to 8°C, under sterile conditions after reconstitution.
3 months, -20°C to -70°C, under sterile conditions after reconstitution.
Molecular Weight
8.8kDa by Mass Spec.
OMIM
602227
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Host Note
Recombinant human CCL19 produced in E. coli (accession no. Q99731).
Preservative
None
Appearance
White powder
Activity
EC50 = 30nM determined by calcium flux with recombinant human CCR7.
Endotoxin Level
<0.01 EU per 1ug of protein by LAL method.
Carrier Protein
None
Reconstitution
Recommended at 100ug/ml in sterile distilled water.

Other Notes

Small volumes of CCL19 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL19 purchase

MBS197063 is an active protein targeting CCL19. Also known as Recombinant CCL19 (MIP-3β). Host: E. coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL19. It may not necessarily be applicable to this product.

NCBI GI #
5454040
NCBI GeneID
6363
NCBI Accession #
NP_006265.1
UniProt Secondary Accession #
O00697; O00736
UniProt Related Accession #
Q99731
GenBank Nucleotide #
NM_006274.2
NCBI Official Full Name
C-C motif chemokine 19
NCBI Official Synonym Full Names
C-C motif chemokine ligand 19
NCBI Official Symbol
CCL19
NCBI Official Synonym Symbols
ELC; CKb11; MIP3B; MIP-3b; SCYA19
UniProt Protein Name
C-C motif chemokine 19
UniProt Synonym Protein Names
Beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; Macrophage inflammatory protein 3 beta; MIP-3-beta; Small-inducible cytokine A19
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL19
UniProt Synonym Gene Names
ELC; MIP3B; SCYA19; EBI1 ligand chemokine; ELC; MIP-3-beta
UniProt Entry Name
CCL19_HUMAN
NCBI Protein Information
C-C motif chemokine 19

NCBI Summary for CCL19

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]
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UniProt Comments for CCL19

CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: cell; extracellular region; extracellular space; intracellular

Molecular Function: CCR chemokine receptor binding; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding; chemokine activity; chemokine receptor binding

Biological Process: activation of JNK activity; cell communication; cell maturation; cellular calcium ion homeostasis; dendritic cell chemotaxis; establishment of T cell polarity; formation of immunological synapse; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; myeloid dendritic cell chemotaxis; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; positive regulation of endocytosis; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling cascade; positive regulation of receptor-mediated endocytosis; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of tumor necrosis factor production; release of sequestered calcium ion into cytosol; response to virus; T cell costimulation
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Research Articles on CCL19

1. CrkL regulates CCL19 and CCR7-induced epithelial-to-mesenchymal transition via ERK signaling pathway in epithelial ovarian carcinoma patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL19 active protein

 Reference Product  PubMed Publications
 CCR7 active protein  >511 publications with CCL19 and CCR7
 CXCL12 active protein  >152 publications with CCL19 and CXCL12
 CXCL13 active protein  >109 publications with CCL19 and CXCL13
 CCL20 active protein  >87 publications with CCL19 and CCL20
 CCL25 active protein  >34 publications with CCL19 and CCL25
 CXCR3 active protein  >30 publications with CCL19 and CXCR3
 CCR1 active protein  >25 publications with CCL19 and CCR1
 CCRL1 active protein  >14 publications with CCL19 and CCRL1
 CCR10 active protein  >12 publications with CCL19 and CCR10
 CCR9 active protein  >10 publications with CCL19 and CCR9

Pathways associated with CCL19 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram

Diseases associated with CCL19 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >182 publications with CCL19 and Inflammation
 Necrosis Antibodies  >71 publications with CCL19 and Necrosis
 Lung Diseases Antibodies  >50 publications with CCL19 and Lung Diseases
 Vascular Diseases Antibodies  >39 publications with CCL19 and Vascular Diseases
 Cardiovascular Diseases Antibodies  >38 publications with CCL19 and Cardiovascular Diseases
 Hypersensitivity Antibodies  >29 publications with CCL19 and Hypersensitivity
 Atherosclerosis Antibodies  >26 publications with CCL19 and Atherosclerosis
 Lung Neoplasms Antibodies  >17 publications with CCL19 and Lung Neoplasms
 Liver Diseases Antibodies  >16 publications with CCL19 and Liver Diseases
 Respiratory Tract Infections Antibodies  >16 publications with CCL19 and Respiratory Tract Infections

Organs/Tissues associated with CCL19 active protein

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >300 publications with CCL19 and Lymph Node
 Vascular Antibodies  >96 publications with CCL19 and Vascular
 Spleen Antibodies  >81 publications with CCL19 and Spleen
 Lung Antibodies  >71 publications with CCL19 and Lung
 Thymus Antibodies  >42 publications with CCL19 and Thymus
 Brain Antibodies  >39 publications with CCL19 and Brain
 Intestine Antibodies  >25 publications with CCL19 and Intestine
 Eye Antibodies  >22 publications with CCL19 and Eye
 Heart Antibodies  >19 publications with CCL19 and Heart
 Pancreas Antibodies  >17 publications with CCL19 and Pancreas
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