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CCL7 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS197068

CCL7, also known as Monocyte Chemotactic Protein-3 (MCP-3), is a secreted chemokine that attracts macrophages, monocytes, and eosinophils during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having… More details

$300 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCL7, Recombinant Protein
Full Product Name
Recombinant CCL7 (MCP-3), biotinylated
Product Gene Name
CCL7 recombinant protein
Product Synonym Gene Name
MCP-3
Product Synonym Names
Recombinant Human CCL7, biotinylated
Preparation and Storage
12 months from date of receipt, -20 degree C to -70 degree C, as supplied. 1 month, 2 degree C to 8 degree C, under sterile conditions after reconstitution. 3 months, -20 degree C to -70 degree C, under sterile conditions after reconstitution.
Molecular Weight
11,200 Da
OMIM
158106

Other Notes

Small volumes of CCL7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL7 purchase

MBS197068 is a recombinant protein targeting CCL7. Also known as Recombinant CCL7 (MCP-3), biotinylated.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL7. It may not necessarily be applicable to this product.

NCBI GI #
13435402
NCBI GeneID
6354
NCBI Accession #
NP_006264.2
UniProt Secondary Accession #
Q569J6
UniProt Related Accession #
P80098
GenBank Nucleotide #
NM_006273.3
NCBI Official Full Name
C-C motif chemokine 7
NCBI Official Synonym Full Names
C-C motif chemokine ligand 7
NCBI Official Symbol
CCL7
NCBI Official Synonym Symbols
FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
UniProt Protein Name
C-C motif chemokine 7
UniProt Synonym Protein Names
Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; NC28; Small-inducible cytokine A7
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL7
UniProt Synonym Gene Names
MCP3; SCYA6; SCYA7; MCP-3
UniProt Entry Name
CCL7_HUMAN
NCBI Protein Information
C-C motif chemokine 7

NCBI Summary for CCL7

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
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UniProt Comments for CCL7

CCL7: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: cell; extracellular region; extracellular space

Molecular Function: CCR1 chemokine receptor binding; CCR2 chemokine receptor binding; chemokine activity; heparin binding; protein binding

Biological Process: cell-cell signaling; cellular calcium ion homeostasis; chemotaxis; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of cell migration; positive regulation of GTPase activity; positive regulation of inflammatory response; regulation of cell shape; response to gamma radiation; signal transduction
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Research Articles on CCL7

1. Periprostatic adipocytes drive prostate cancer progression in obesity via CCL7 secretion which stimulates CCR3 expressing tumor cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL7 recombinant protein

 Reference Product  PubMed Publications
 CCL2 recombinant protein  >303 publications with CCL7 and CCL2
 CCR2 recombinant protein  >102 publications with CCL7 and CCR2
 CCL3 recombinant protein  >89 publications with CCL7 and CCL3
 CCL4 recombinant protein  >89 publications with CCL7 and CCL4
 CCR3 recombinant protein  >51 publications with CCL7 and CCR3
 CCR1 recombinant protein  >48 publications with CCL7 and CCR1
 CCR5 recombinant protein  >40 publications with CCL7 and CCR5
 CXCR3 recombinant protein  >10 publications with CCL7 and CXCR3
 CCR10 recombinant protein  >3 publications with CCL7 and CCR10

Pathways associated with CCL7 recombinant protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with CCL7 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >219 publications with CCL7 and Inflammation
 Respiratory Tract Diseases Antibodies  >72 publications with CCL7 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >62 publications with CCL7 and Lung Diseases
 Disease Models, Animal Antibodies  >61 publications with CCL7 and Disease Models, Animal
 Necrosis Antibodies  >58 publications with CCL7 and Necrosis
 Hypersensitivity Antibodies  >56 publications with CCL7 and Hypersensitivity
 Cardiovascular Diseases Antibodies  >31 publications with CCL7 and Cardiovascular Diseases
 Fibrosis Antibodies  >24 publications with CCL7 and Fibrosis
 Atherosclerosis Antibodies  >16 publications with CCL7 and Atherosclerosis
 Heart Diseases Antibodies  >14 publications with CCL7 and Heart Diseases

Organs/Tissues associated with CCL7 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >302 publications with CCL7 and Blood
 Lung Antibodies  >78 publications with CCL7 and Lung
 Skin Antibodies  >38 publications with CCL7 and Skin
 Intestine Antibodies  >15 publications with CCL7 and Intestine
 Uterus Antibodies  >10 publications with CCL7 and Uterus
 Placenta Antibodies  >4 publications with CCL7 and Placenta
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