• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Synaptobrevin 2 (VAMP2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200052

Synaptobrevin 2 (Vesicle-associated membrane, VAMP2), which is an 18 kDa integral membrane protein localized to the cytoplasmic surface of synaptic vesicle, consists of a proline-rich N-terminal region, a highly conserved hydrophilic domain, followed by a… More details

$285 / 0.05 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Synaptobrevin 2 (VAMP2), Monoclonal Antibody
Full Product Name
Synaptobrevin 2 antibody
Product Gene Name
anti-VAMP2 antibody
Product Synonym Names
vesicle-associated membrane protein 2; VAMP2; SYB2; Synaptobrevin 2; VAMP-2; Synaptobrevin-2; Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 FLJ11460; RATVAMPB; RATVAMPIR; SYB; VAMP 2; Vesicle associated membrane protein 2; Vesicle-associated membrane protein 2 (synaptobrevin 2).
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
3E5
Host
Mouse
Species Reactivity
Human, Rat
Form/Format
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
Purity/Purification
By protein-G affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
3D Structure
ModBase 3D Structure for P63027
Immunogen
Recombinant human Synaptobrevin 2 (1-89aa) purified from E. coli

Product Categories/Family for anti-VAMP2 antibody

Neuroscience
Applications Tested/Suitable for anti-VAMP2 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-VAMP2 antibody
Since application varies, however, each investigation should be titrated by reagen to optain optimal results.

Western Blot (WB) of anti-VAMP2 antibody

Mouse Anti-VAMP2 Monoclonal Antibody – Cat# MBS200052

Western Blot (WB) of anti-VAMP2 antibody

Mouse Anti-VAMP2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS200052

Western Blot (WB) of anti-VAMP2 antibody

Mouse Anti-VAMP2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS200052

Immunofluorescence (IF) of anti-VAMP2 antibody

Mouse Anti-VAMP2 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS200052

Product References and Citations for anti-VAMP2 antibody

Andres C et al., (1995) Proc Natl Acad Sci USA 92:5987-5991; Jacobsson G et al., (1998) European Journal of Neuroscience 16:301-316; Scales SJ. et al (2002) J Biol. Chem. 227 (31):28271-28279; Pennuto M et al., (2003) Mol Biol Cell. 14:4909-19

Other Notes

Small volumes of anti-VAMP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VAMP2 purchase

MBS200052 is an antibody targeting VAMP2. Also known as Synaptobrevin 2 antibody. Reactive in Human, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for VAMP2. It may not necessarily be applicable to this product.

NCBI GI #
172072620
NCBI GeneID
6844
NCBI Accession #
NP_055047
UniProt Primary Accession #
P63027
UniProt Secondary Accession #
P19065; Q9BUC2
UniProt Related Accession #
P63027
GenBank Nucleotide #
NM_014232.2
NCBI Official Full Name
vesicle-associated membrane protein 2 isoform 1
NCBI Official Synonym Full Names
vesicle associated membrane protein 2
NCBI Official Symbol
VAMP2
NCBI Official Synonym Symbols
SYB2; VAMP-2
UniProt Protein Name
Vesicle-associated membrane protein 2
UniProt Synonym Protein Names
Synaptobrevin-2
Protein Family
Vesicle-associated membrane protein
UniProt Gene Name
VAMP2
UniProt Synonym Gene Names
SYB2; VAMP-2
NCBI Protein Information
vesicle-associated membrane protein 2

NCBI Summary for VAMP2

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for VAMP2

Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Research Articles on VAMP2

1. Data suggest that A-syn (alpha-synuclein) promotes SNARE-dependent vesicle docking; phosphatidylserine (PS) removal from t-SNARE-bearing vesicles causes A-syn to inhibit vesicle docking; PS removal from v-SNARE-bearing vesicles promotes vesicle docking; the C-terminal 45 residues of A-syn are required for promotion of vesicle docking. (Here, t-SNARE is SNAP-25; v-SNARE is VAMP2.)
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VAMP2 antibody

 Reference Product  PubMed Publications
 SNAP25 antibody  >115 publications with VAMP2 and SNAP25
 SNAP23 antibody  >53 publications with VAMP2 and SNAP23
 STX1A antibody  >40 publications with VAMP2 and STX1A
 SYT1 antibody  >25 publications with VAMP2 and SYT1
 STXBP1 antibody  >11 publications with VAMP2 and STXBP1
 STX4 antibody  >4 publications with VAMP2 and STX4
 SNAP29 antibody  >1 publications with VAMP2 and SNAP29
 STX3 antibody  >1 publications with VAMP2 and STX3
 NAPA antibody  >1 publications with VAMP2 and NAPA
 STX6 antibody  >1 publications with VAMP2 and STX6

Pathways associated with anti-VAMP2 antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Neurotransmitter Release Cycle Pathway antibodies  Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
 Cargo Recognition For Clathrin-mediated Endocytosis Pathway antibodies  Cargo Recognition For Clathrin-mediated Endocytosis Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Clathrin-mediated Endocytosis Pathway antibodies  Clathrin-mediated Endocytosis Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Dopamine Neurotransmitter Release Cycle Pathway antibodies  Dopamine Neurotransmitter Release Cycle Pathway Diagram
 Effects Of Botulinum Toxin Pathway antibodies  Effects Of Botulinum Toxin Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram

Diseases associated with anti-VAMP2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >57 publications with VAMP2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >32 publications with VAMP2 and Disease Models, Animal
 Inflammation Antibodies  >12 publications with VAMP2 and Inflammation
 Seizures Antibodies  >10 publications with VAMP2 and Seizures
 Cognition Disorders Antibodies  >9 publications with VAMP2 and Cognition Disorders
 Depressive Disorder Antibodies  >7 publications with VAMP2 and Depressive Disorder
 Cardiovascular Diseases Antibodies  >6 publications with VAMP2 and Cardiovascular Diseases
 Memory Disorders Antibodies  >6 publications with VAMP2 and Memory Disorders
 Movement Disorders Antibodies  >6 publications with VAMP2 and Movement Disorders
 Neurobehavioral Manifestations Antibodies  >6 publications with VAMP2 and Neurobehavioral Manifestations

Organs/Tissues associated with anti-VAMP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >257 publications with VAMP2 and Brain
 Nerve Antibodies  >189 publications with VAMP2 and Nerve
 Muscle Antibodies  >89 publications with VAMP2 and Muscle
 Blood Antibodies  >46 publications with VAMP2 and Blood
 Pancreas Antibodies  >45 publications with VAMP2 and Pancreas
 Kidney Antibodies  >29 publications with VAMP2 and Kidney
 Eye Antibodies  >22 publications with VAMP2 and Eye
 Heart Antibodies  >16 publications with VAMP2 and Heart
 Embryonic Tissue Antibodies  >16 publications with VAMP2 and Embryonic Tissue
 Lung Antibodies  >15 publications with VAMP2 and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000