Mouse Anti-PTHR2 Monoclonal Antibody – Cat# MBS2001261

Parathyroid Hormone Receptor 2 (PTHR2) Antibody – Mouse Monoclonal

Name: PTHR2 Antibody; Monoclonal; Mouse; Dog-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2001261
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2001261

MBS2001261 is an antibody targeting PTHR2. Also known as Monoclonal Antibody to Parathyroid Hormone Receptor 2 (PTHR2). Reactive in Dog. Host: Mouse. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Parathyroid Hormone Receptor 2 (PTHR2), Monoclonal Antibody

Full Product Name

Monoclonal Antibody to Parathyroid Hormone Receptor 2 (PTHR2)

Product Gene Name

anti-PTHR2 antibody

Clonality

Monoclonal

Host

Mouse

Species Reactivity

Dog

Form/Format

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

Purity/Purification

Affinity Chromatography

Concentration

1mg/mL (lot specific)

Specificity

The antibody is a mouse monoclonal antibody raised against PTHR2. It has been selected for its ability to recognize PTHR2 in immunohistochemical staining andwestern blotting.

Preparation and Storage

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Molecular Weight

62,236 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (209224569..209359231). Location: 2q33

OMIM

601469

3D Structure

ModBase 3D Structure for P49190

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-PTHR2 antibody

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

Application Notes for anti-PTHR2 antibody

Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Other Notes

Small volumes of anti-PTHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PTHR2. It may not necessarily be applicable to this product.

NCBI GI #

4826954

NCBI GeneID

5746

NCBI Accession #

NP_005039.1

UniProt Primary Accession #

P49190

UniProt Secondary Accession #

Q8N429

UniProt Related Accession #

P49190

GenBank Nucleotide #

NM_005048.3

NCBI Official Full Name

parathyroid hormone 2 receptor

NCBI Official Synonym Full Names

parathyroid hormone 2 receptor

NCBI Official Symbol

PTH2R

NCBI Official Synonym Symbols

PTHR2

UniProt Protein Name

Parathyroid hormone 2 receptor

UniProt Gene Name

PTH2R

UniProt Synonym Gene Names

PTHR2; PTH2 receptor

UniProt Entry Name

PTH2R_HUMAN

NCBI Protein Information

parathyroid hormone 2 receptor; PTH2 receptor; parathyroid hormone receptor 2

NCBI Summary for PTHR2

The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

UniProt Comments for PTHR2

PTH2R: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: parathyroid hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway

Research Articles on PTHR2

1. Data suggest role for PTH2R signaling in postnatal growth plate development and subsequent bone mass acquisition; overexpression of human PTH2R in chondrocytes of transgenic mice has key consequences on postnatal development of endochondral skeleton.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTHR2 antibody

Reference Product	PubMed Publications
PTH antibody	>17 publications with PTHR2 and PTH
PTH2 antibody	>6 publications with PTHR2 and PTH2
PTHLH antibody	>3 publications with PTHR2 and PTHLH
CRH antibody	>1 publications with PTHR2 and CRH

Pathways associated with anti-PTHR2 antibody

Products by Pathway	Pathway Diagram
Class B/2 (Secretin Family Receptors) Pathway antibodies	Class B/2 (Secretin Family Receptors) Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class B Secretin-like Pathway antibodies	GPCRs, Class B Secretin-like Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-PTHR2 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3 publications with PTHR2 and Nervous System Diseases
Inflammation Antibodies	>1 publications with PTHR2 and Inflammation
Leukemia Antibodies	>1 publications with PTHR2 and Leukemia
Seizures Antibodies	>1 publications with PTHR2 and Seizures
Neoplasms Antibodies	>1 publications with PTHR2 and Neoplasms
Learning Disorders Antibodies	>1 publications with PTHR2 and Learning Disorders

Organs/Tissues associated with anti-PTHR2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>13 publications with PTHR2 and Brain
Lung Antibodies	>1 publications with PTHR2 and Lung
Testis Antibodies	>1 publications with PTHR2 and Testis
Bone Marrow Antibodies	>1 publications with PTHR2 and Bone Marrow
Skin Antibodies	>1 publications with PTHR2 and Skin