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Anti-Mullerian Hormone (AMH) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001312
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MBS2001312 is an antibody targeting AMH. Also known as Monoclonal Antibody to Anti-Mullerian Hormone (AMH). Reactive in Human, Bovine. Host: Mouse. More details

$295 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Anti-Mullerian Hormone (AMH), Monoclonal Antibody
Full Product Name
Monoclonal Antibody to Anti-Mullerian Hormone (AMH)
Product Gene Name
anti-AMH antibody
Clonality
Monoclonal
Isotype
IgG2b Kappa
Clone Number
4-1#
Host
Mouse
Species Reactivity
Human, Bovine
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Protein A + Protein G affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: AMH Clone #4-1# (MBS2001312)
APC-CY7 Conjugated Antibody: AMH Clone #4-1# (MBS2039899)
Matching Pairs
Unconjugated Antibody: AMH Clone #4-1# (MBS2001312)
PE Conjugated Antibody: AMH Clone #4-1# (MBS2039901)
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OMIM
K03474 Genomic DNA
3D Structure
ModBase 3D Structure for P03971
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Organism Species
Homo sapiens (Human)
Source
Monoclonal antibody preparation
Cross Reactivity
Human, Bovine
Traits
Liquid
Immunogen
Recombinant AMH expressed in E.coli
Unconjugated Antibody
MBS2010947
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-AMH antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-AMH antibody
Western blotting: 0.5-5ug/mL
Immunohistochemistry: 5-50ug/mL
Immunocytochemistry: 5-50ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-AMH antibody

Western Blot; Sample: Recombinant AMH, Human.
Mouse Anti-AMH Monoclonal Antibody – Cat# MBS2001312

Western Blot (WB) of anti-AMH antibody

Western Blot; Sample: Bovine Testis lysate;
Primary Ab: 3ug/ml Mouse Anti-Human AMH Antibody
Second Ab: 0.2ug/ml HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: MBS2086035 )
Mouse Anti-AMH Monoclonal Antibody, Western Blot (WB) – Cat# MBS2001312

Immunohistochemistry (IHC) of anti-AMH antibody

DAB staining on IHC-P;
Samples: Human Pancreas Tissue;
Primary Ab: 40ug/ml Mouse Anti-Human AMH Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: MBS2086035 )
Mouse Anti-AMH Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001312

Other Notes

Small volumes of anti-AMH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AMH. It may not necessarily be applicable to this product.

NCBI GI #
157266298
NCBI GeneID
268
NCBI Accession #
NP_000470.2
UniProt Primary Accession #
P03971
UniProt Secondary Accession #
O75246; Q6GTN3
UniProt Related Accession #
P03971
GenBank Nucleotide #
NM_000479.4
NCBI Official Full Name
muellerian-inhibiting factor preproprotein
NCBI Official Synonym Full Names
anti-Mullerian hormone
NCBI Official Symbol
AMH
NCBI Official Synonym Symbols
MIF; MIS
UniProt Protein Name
Muellerian-inhibiting factor
UniProt Synonym Protein Names
Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS
Protein Family
Muellerian-inhibiting factor
UniProt Gene Name
AMH
UniProt Synonym Gene Names
MIF; AMH; MIS
NCBI Protein Information
muellerian-inhibiting factor

NCBI Summary for AMH

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
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UniProt Comments for AMH

AMH: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS1). PMDS1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular region; extracellular space

Molecular Function: growth factor activity; hormone activity; receptor binding; transforming growth factor beta receptor binding

Biological Process: aging; BMP signaling pathway; cell-cell signaling; gonadal mesoderm development; Mullerian duct regression; positive regulation of NF-kappaB transcription factor activity; preantral ovarian follicle growth; response to drug; response to organic cyclic compound; sex determination; sex differentiation; urogenital system development

Disease: Persistent Mullerian Duct Syndrome, Types I And Ii
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Research Articles on AMH

1. Women with unexplained infertility did not show evidence of decreased ovarian reserve as measured by AMH and antral follicle count.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AMH antibody

 Reference Product  PubMed Publications
 FSH antibody  >545 publications with AMH and FSH
 SOX9 antibody  >75 publications with AMH and SOX9
 AMHR2 antibody  >32 publications with AMH and AMHR2
 GATA4 antibody  >21 publications with AMH and GATA4
 KITLG antibody  >13 publications with AMH and KITLG
 ZFPM2 antibody  >3 publications with AMH and ZFPM2
 SMAD5 antibody  >3 publications with AMH and SMAD5
 SMAD9 antibody  >1 publications with AMH and SMAD9
 ACVR1 antibody  >1 publications with AMH and ACVR1

Pathways associated with anti-AMH antibody

 Products by Pathway  Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram

Diseases associated with anti-AMH antibody

 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >549 publications with AMH and Female Urogenital Diseases
 Gonadal Disorders Antibodies  >449 publications with AMH and Gonadal Disorders
 Neoplasms Antibodies  >309 publications with AMH and Neoplasms
 Ovarian Diseases Antibodies  >306 publications with AMH and Ovarian Diseases
 Infertility, Female Antibodies  >264 publications with AMH and Infertility, Female
 Urogenital Abnormalities Antibodies  >151 publications with AMH and Urogenital Abnormalities
 Genital Diseases, Male Antibodies  >129 publications with AMH and Genital Diseases, Male
 Disorders of Sex Development Antibodies  >129 publications with AMH and Disorders of Sex Development
 Infertility, Male Antibodies  >76 publications with AMH and Infertility, Male
 Testicular Diseases Antibodies  >65 publications with AMH and Testicular Diseases

Organs/Tissues associated with anti-AMH antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >319 publications with AMH and Testis
 Uterus Antibodies  >66 publications with AMH and Uterus
 Brain Antibodies  >50 publications with AMH and Brain
 Embryonic Tissue Antibodies  >47 publications with AMH and Embryonic Tissue
 Lung Antibodies  >19 publications with AMH and Lung
 Prostate Antibodies  >12 publications with AMH and Prostate
 Intestine Antibodies  >9 publications with AMH and Intestine
 Eye Antibodies  >4 publications with AMH and Eye
 Stomach Antibodies  >2 publications with AMH and Stomach
 Mammary Gland Antibodies  >2 publications with AMH and Mammary Gland
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