B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L) Antibody – Mouse Monoclonal

Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.

Protein type: Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 3q41

Cellular Component: cell junction; centrosome; clathrin-coated pit; cytoplasm; cytosol; endoplasmic reticulum; integral component of membrane; intracellular; membrane; mitochondrial envelope; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nuclear membrane; presynapse; synaptic vesicle membrane

Molecular Function: BH domain binding; BH3 domain binding; caspase inhibitor activity; clathrin binding; GTPase binding; identical protein binding; protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; transcription factor binding

Biological Process: aging; apoptosis; apoptotic process in bone marrow; cell proliferation; cellular process regulating host cell cycle in response to virus; cellular response to alkaloid; cellular response to astaxanthin; cellular response to cAMP; cellular response to dexamethasone stimulus; cellular response to gamma radiation; cellular response to hypoxia; cellular response to interleukin-1; cellular response to prolactin; cellular response to thapsigargin; cellular response to tumor necrosis factor; cerebral cortex development; DNA damage response, signal transduction resulting in induction of apoptosis; endocytosis; fertilization; germ cell development; growth; in utero embryonic development; male gonad development; mitotic cell cycle checkpoint; negative regulation of anoikis; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of execution phase of apoptosis; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of neuron apoptosis; negative regulation of release of cytochrome c from mitochondria; neuron apoptosis; ovarian follicle development; positive regulation of apoptosis; positive regulation of ATP biosynthetic process; positive regulation of cell proliferation; positive regulation of synaptic vesicle clustering; positive regulation of synaptic vesicle endocytosis; positive regulation of synaptic vesicle exocytosis; regulation of apoptosis; regulation of long term synaptic depression; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to cycloheximide; response to cytokine; response to drug; response to electrical stimulus; response to hydrogen peroxide; response to hypoxia; response to inorganic substance; response to lead ion; response to lipopolysaccharide; response to organic cyclic compound; response to organonitrogen compound; response to oxidative stress; response to peptide hormone; response to radiation; response to virus; spermatogenesis; suppression by virus of host apoptotic process; synaptic vesicle recycling via endosome