Matrix Metalloproteinase 12 (MMP12) Antibody – Rabbit Polyclonal

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

MMP12: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. Belongs to the peptidase M10A family.

Protein type: EC 3.4.24.65; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q22.2

Cellular Component: cytoplasm; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; collagen binding; endopeptidase activity; metalloendopeptidase activity; sequence-specific DNA binding; serine-type endopeptidase activity; zinc ion binding

Biological Process: collagen catabolic process; extracellular matrix disassembly; negative regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus; proteolysis; regulation of defense response to virus by host; wound healing, spreading of epidermal cells