Rabbit Anti-IGFBP3 Polyclonal Antibody – Cat# MBS2001418

Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Antibody – Rabbit Polyclonal

Name: IGFBP3 Antibody; Polyclonal; Rabbit; Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2001418
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2001418

MBS2001418 is an antibody targeting IGFBP3. Also known as Biotin-Linked Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3). Reactive in Mouse, Rat. Host: Rabbit. More details

$220 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Insulin Like Growth Factor Binding Protein 3 (IGFBP3), Polyclonal Antibody

Full Product Name

Biotin-Linked Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3)

Product Gene Name

anti-IGFBP3 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse, Rat

Form/Format

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

Purity/Purification

Affinity Chromatography

Concentration

500ug/ml (lot specific)

Specificity

The antibody is a rabbit polyclonal antibody raised against IGFBP3 conjugated to biotin. It has been selected for its ability to recognize IGFBP3 in immunohistochemical staining andwestern blotting.

Preparation and Storage

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Matching Pairs

Biotin Conjugated Antibody: IGFBP3 (MBS2001418)
Immunogen: IGFBP3 (MBS2009715)

Matching Pairs

Unconjugated Antibody: IGFBP3 (MBS2006016)
Biotin Conjugated Antibody: IGFBP3 (MBS2001418)

Molecular Weight

31,570 Da

Chromosome Location

Chromosome: 4; AC_000161.1 (76705105..76713511). Location: chromosome: 4

3D Structure

ModBase 3D Structure for P20959

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Product Categories/Family for anti-IGFBP3 antibody

Biotin Antibody

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-IGFBP3 antibody

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

Application Notes for anti-IGFBP3 antibody

Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Other Notes

Small volumes of anti-IGFBP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IGFBP3. It may not necessarily be applicable to this product.

NCBI GI #

27807007

NCBI GeneID

282261

NCBI Accession #

NP_776981.1

UniProt Primary Accession #

P20959

UniProt Secondary Accession #

Q9GJV5; A6QPI3

UniProt Related Accession #

P20959

GenBank Nucleotide #

NM_174556.1

NCBI Official Full Name

insulin-like growth factor-binding protein 3

NCBI Official Synonym Full Names

insulin-like growth factor binding protein 3<

NCBI Official Symbol

IGFBP3

NCBI Official Synonym Symbols

IGFBP-3

UniProt Protein Name

Insulin-like growth factor-binding protein 3

Protein Family

Insulin-like growth factor-binding protein

UniProt Gene Name

IGFBP3

UniProt Synonym Gene Names

IBP-3; IGF-binding protein 3; IGFBP-3

UniProt Entry Name

IBP3_BOVIN

NCBI Protein Information

insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; insulin-like growth factor binding protein-3

UniProt Comments for IGFBP3

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Subunit structure: Interacts with HN. Interacts with TMEM219

By similarity. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with XLKD1. Ref.6

Subcellular location: Secreted.

Tissue specificity: Plasma; expressed by most tissues.

Post-translational modification: Phosphorylation sites are present in the extracellular medium

By similarity.

Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.

Research Articles on IGFBP3

1. The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IGFBP3 antibody

Reference Product	PubMed Publications
IGF1 antibody	>190 publications with IGFBP3 and IGF1
IGF2 antibody	>68 publications with IGFBP3 and IGF2
IGFALS antibody	>18 publications with IGFBP3 and IGFALS
PRL antibody	>18 publications with IGFBP3 and PRL
TP53 antibody	>11 publications with IGFBP3 and TP53
INS antibody	>6 publications with IGFBP3 and INS
BMP4 antibody	>5 publications with IGFBP3 and BMP4
FN1 antibody	>1 publications with IGFBP3 and FN1

Pathways associated with anti-IGFBP3 antibody

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies	Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram
P53 Signaling Pathway antibodies	P53 Signaling Pathway Diagram
P53 Signaling Pathway antibodies	P53 Signaling Pathway Diagram

Diseases associated with anti-IGFBP3 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1218 publications with IGFBP3 and Neoplasms
Breast Neoplasms Antibodies	>331 publications with IGFBP3 and Breast Neoplasms
Prostatic Neoplasms Antibodies	>251 publications with IGFBP3 and Prostatic Neoplasms
Cardiovascular Diseases Antibodies	>211 publications with IGFBP3 and Cardiovascular Diseases
Adenocarcinoma Antibodies	>165 publications with IGFBP3 and Adenocarcinoma
Colorectal Neoplasms Antibodies	>140 publications with IGFBP3 and Colorectal Neoplasms
Liver Diseases Antibodies	>138 publications with IGFBP3 and Liver Diseases
Kidney Diseases Antibodies	>120 publications with IGFBP3 and Kidney Diseases
Inflammation Antibodies	>119 publications with IGFBP3 and Inflammation
Necrosis Antibodies	>106 publications with IGFBP3 and Necrosis

Organs/Tissues associated with anti-IGFBP3 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>404 publications with IGFBP3 and Liver
Muscle Antibodies	>285 publications with IGFBP3 and Muscle
Kidney Antibodies	>201 publications with IGFBP3 and Kidney
Brain Antibodies	>194 publications with IGFBP3 and Brain
Lung Antibodies	>172 publications with IGFBP3 and Lung
Ovary Antibodies	>157 publications with IGFBP3 and Ovary
Skin Antibodies	>107 publications with IGFBP3 and Skin
Uterus Antibodies	>71 publications with IGFBP3 and Uterus
Pituitary Gland Antibodies	>68 publications with IGFBP3 and Pituitary Gland
Intestine Antibodies	>65 publications with IGFBP3 and Intestine