Hedgehog Homolog, Desert (DHH) Antibody – Rabbit Polyclonal

DHH: Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development. Defects in DHH may be the cause of partial gonadal dysgenesis with minifascicular neuropathy 46,XY (PGD). PGD is characterized by the presence of a testis on one side and a streak or an absent gonad at the other, persistence of Muellerian duct structures, and a variable degree of genital ambiguity. Defects in DHH may be the cause of complete pure gonadal dysgenesis 46,XY type (GDXYM); also known as male- limited gonadal dysgenesis 46,XY. GDXYM is a type of hypogonadism in which no functional gonads are present to induce puberty in an externally female person whose karyotype is then found to be XY. The gonads are found to be non-functional streaks. Belongs to the hedgehog family.

Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15 F1|15 55.05 cM

Cellular Component: extracellular region; membrane; plasma membrane

Molecular Function: calcium ion binding; hydrolase activity; metal ion binding; patched binding; peptidase activity; protein binding; zinc ion binding

Biological Process: cell-cell signaling; intein-mediated protein splicing; Leydig cell differentiation; male sex determination; multicellular organism development; osteoblast differentiation; proteolysis; regulation of steroid biosynthetic process; smoothened signaling pathway; spermatid development