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Renin (REN) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001487
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MBS2001487 is an antibody targeting REN. Also known as Polyclonal Antibody to Renin (REN). Reactive in Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Renin (REN), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Renin (REN)
Product Gene Name
anti-REN antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- TIHYGSG KVKGFLSQDV VTVGGIIVTQ TFGEVTELPL IPFMLAKFDG VLGMGFPAQA VDGVIPVFDH ILSQRVLKEE VFSVYYSRES HLLGGEV
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against REN. It has been selected for its ability to recognize REN in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: REN (MBS2001487)
Immunogen: REN (MBS2009470)
Matching Pairs
Unconjugated Antibody: REN (MBS2001487)
APC-CY7 Conjugated Antibody: REN (MBS2049223)
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Molecular Weight
44,276 Da
3D Structure
ModBase 3D Structure for P08424
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant REN (Thr144~Val237) expressed in E.coli.
Cross Reactivity
Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2049229
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-REN antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-REN antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-REN antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-REN Polyclonal Antibody – Cat# MBS2001487

Immunohistochemistry (IHC) of anti-REN antibody

DAB staining on fromalin fixed paraffin- embedded testis tissue)
Rabbit Anti-REN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001487

Immunohistochemistry (IHC) of anti-REN antibody

DAB staining on IHC-P; Samples: Rat Cerebrum Tissue)
Rabbit Anti-REN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001487

Other Notes

Small volumes of anti-REN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for REN. It may not necessarily be applicable to this product.

NCBI GI #
148747255
NCBI GeneID
24715
NCBI Accession #
NP_036774.4
UniProt Primary Accession #
P08424
UniProt Secondary Accession #
Q63497
UniProt Related Accession #
P08424
GenBank Nucleotide #
NM_012642.4
NCBI Official Full Name
renin
NCBI Official Synonym Full Names
renin
NCBI Official Symbol
Ren
NCBI Official Synonym Symbols
Ren1; RENAA; RATRENAA
UniProt Protein Name
Renin
UniProt Synonym Protein Names
Angiotensinogenase
Protein Family
Protein
UniProt Gene Name
Ren1
UniProt Synonym Gene Names
Ren
NCBI Protein Information
renin

NCBI Summary for REN

catalyzes the cleavage of a Leu-Xaa bond in angiotensinogen to generate angiotensin [RGD, Feb 2006]

UniProt Comments for REN

REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.15; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q13

Cellular Component: apical part of cell; cytoplasm; extracellular space; intracellular; membrane

Molecular Function: aspartic-type endopeptidase activity; endopeptidase activity; insulin-like growth factor receptor binding; peptidase activity; receptor binding

Biological Process: angiotensin maturation; beta-amyloid metabolic process; cell maturation; drinking behavior; establishment of blood-nerve barrier; hormone-mediated signaling pathway; kidney development; male gonad development; mesonephros development; protein catabolic process; proteolysis; regulation of blood pressure; regulation of blood volume by renin-angiotensin; regulation of MAPK cascade; renin-angiotensin regulation of aldosterone production; response to cAMP; response to drug; response to lipopolysaccharide; response to organic substance
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Research Articles on REN

1. An alternative promoter in intron1 of the renin gene is regulated by glucose starvation via SRF.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-REN antibody

 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin - Angiotensin System Pathway antibodies  Renin - Angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram

Diseases associated with anti-REN antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >711 publications with REN and Heart Diseases
 Hypertension Antibodies  >569 publications with REN and Hypertension
 Drug Toxicity Antibodies  >558 publications with REN and Drug Toxicity
 Necrosis Antibodies  >471 publications with REN and Necrosis
 Kidney Diseases Antibodies  >336 publications with REN and Kidney Diseases
 Myocardial Ischemia Antibodies  >316 publications with REN and Myocardial Ischemia
 Ischemia Antibodies  >301 publications with REN and Ischemia
 Fibrosis Antibodies  >285 publications with REN and Fibrosis
 Myocardial Infarction Antibodies  >198 publications with REN and Myocardial Infarction
 Hemorrhage Antibodies  >175 publications with REN and Hemorrhage

Organs/Tissues associated with anti-REN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1223 publications with REN and Brain
 Kidney Antibodies  >749 publications with REN and Kidney
 Eye Antibodies  >398 publications with REN and Eye
 Uncharacterized Tissue Antibodies  >5 publications with REN and Uncharacterized Tissue
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