Mitogen Activated Protein Kinase 8 (MAPK8) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

JNK1: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, pro-inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. Substrates include a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2, thus regulating AP-1 transcriptional activity. In T- cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Activity increased in obesity. Inhibition or mouse knockout increases insulin sensitivity. Part of NFB pathway involved in inflammation and cancer, and signals downstream of Ras, though possibly as an apoptotic negative regulator of growth. Four alternatively-spliced isoforms have been described.

Protein type: CMGC group; EC 2.7.11.24; JNK subfamily; Kinase, protein; MAPK family; MAPK/JNK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: axon; cytoplasm; cytosol; mitochondrion; neuron projection; nucleoplasm; nucleus

Molecular Function: ATP binding; enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; protein binding; protein serine/threonine kinase activity

Biological Process: cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to reactive oxygen species; Fc-epsilon receptor signaling pathway; JNK cascade; JUN phosphorylation; negative regulation of apoptosis; negative regulation of protein binding; neuron development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of apoptosis; positive regulation of cyclase activity; positive regulation of deacetylase activity; positive regulation of gene expression; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of protein metabolic process; protein amino acid phosphorylation; regulation of circadian rhythm; regulation of DNA replication origin binding; regulation of histone deacetylation; regulation of macroautophagy; regulation of protein localization; regulation of transcription factor activity; response to stress; response to UV; rhythmic process; stress-activated MAPK cascade