Macrophage Migration Inhibitory Factor (MIF) Antibody – Rabbit Polyclonal

MIF: a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. Also acts as a phenylpyruvate tautomerase.

Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC 5.3.2.1; EC 5.3.3.12; Isomerase

Chromosomal Location of Human Ortholog: 10 38.59 cM|10 C1

Cellular Component: cell surface; cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular space; myelin sheath; nucleoplasm; nucleus; vesicle

Molecular Function: chemoattractant activity; cytokine activity; cytokine receptor binding; dopachrome isomerase activity; identical protein binding; isomerase activity; phenylpyruvate tautomerase activity; protease binding; protein complex binding; receptor binding

Biological Process: brain renin-angiotensin system; carboxylic acid metabolic process; cell aging; cell proliferation; cell surface receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; drinking behavior; immune system process; inflammatory response; innate immune response; negative regulation of apoptosis; negative regulation of cell aging; negative regulation of cell cycle arrest; negative regulation of cellular protein metabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of macrophage chemotaxis; negative regulation of mature B cell apoptosis; negative regulation of myeloid cell apoptosis; positive regulation of acute inflammatory response; positive regulation of adaptive immune response; positive regulation of arachidonic acid secretion; positive regulation of axon regeneration; positive regulation of B cell proliferation; positive regulation of chemokine (C-X-C motif) ligand 2 production; positive regulation of cytokine secretion; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of glucose import; positive regulation of glycolysis; positive regulation of immune response; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of MAP kinase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of potassium ion transport; positive regulation of protein kinase A signaling; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of tumor necrosis factor production; prostaglandin biosynthetic process; regulation of cell proliferation; spermatogenesis