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Peroxidasin Homolog (PXDN) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001518
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2001518 is an antibody targeting PXDN. Also known as Polyclonal Antibody to Peroxidasin Homolog (PXDN). Reactive in Human. Host: Rabbit. More details

$225 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Peroxidasin Homolog (PXDN), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Peroxidasin Homolog (PXDN)
Product Gene Name
anti-PXDN antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: PXDN (MBS2001518)
Biotin Conjugated Antibody: PXDN (MBS2001554)
Matching Pairs
Unconjugated Antibody: PXDN (MBS2001518)
Immunogen: PXDN (MBS2010846)
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OMIM
AF200348 mRNA
3D Structure
ModBase 3D Structure for Q92626
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Cross Reactivity
Mouse, Rat
Immunogen
Recombinant PXDN (Gln1285~Ala1475) expressed in E.coli (MBS2010846).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-PXDN antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP)
Application Notes for anti-PXDN antibody
Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-PXDN antibody

Western Blot:
Sample: Recombinant PXDN, Human.
Rabbit Anti-PXDN Polyclonal Antibody – Cat# MBS2001518

Immunohistochemistry (IHC) of anti-PXDN antibody

DAB stainingon IHC-P.
Samples: Human Tissue
Rabbit Anti-PXDN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001518

Other Notes

Small volumes of anti-PXDN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PXDN. It may not necessarily be applicable to this product.

NCBI GI #
109150416
NCBI GeneID
7837
NCBI Accession #
NP_036425.1
UniProt Primary Accession #
Q92626
UniProt Secondary Accession #
Q4KMG2; A8QM65; D6W4Y0
UniProt Related Accession #
Q92626
GenBank Nucleotide #
NM_012293.2
NCBI Official Full Name
peroxidasin homolog
NCBI Official Synonym Full Names
peroxidasin
NCBI Official Symbol
PXDN
NCBI Official Synonym Symbols
PXN; VPO; MG50; PRG2; ASGD7; COPOA; D2S448; D2S448E
UniProt Protein Name
Peroxidasin homolog
UniProt Synonym Protein Names
Melanoma-associated antigen MG50; Vascular peroxidase 1; p53-responsive gene 2 protein
UniProt Gene Name
PXDN
UniProt Synonym Gene Names
KIAA0230; MG50; PRG2; VPO; VPO1
NCBI Protein Information
peroxidasin homolog

NCBI Summary for PXDN

This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014]
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UniProt Comments for PXDN

PXDN: Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. Belongs to the peroxidase family. XPO subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.11.1.7; Oxidoreductase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: extracellular matrix structural constituent; heme binding; interleukin-1 receptor antagonist activity; metal ion binding; peroxidase activity

Biological Process: extracellular matrix organization; hydrogen peroxide catabolic process; immune response; negative regulation of cytokine and chemokine mediated signaling pathway; response to oxidative stress

Disease: Corneal Opacification With Other Ocular Anomalies
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Research Articles on PXDN

1. VPO1 plays a critical role in asymmetric dimethylarginine production via H2O2-VPO1-hypochlorous acid pathways, which may contribute to endothelial dysfunction in hypertension.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PXDN antibody

 Disease Name  Pubmed Publications
 Eye Diseases Antibodies  >2 publications with PXDN and Eye Diseases
 Inflammation Antibodies  >2 publications with PXDN and Inflammation
 Nervous System Diseases Antibodies  >1 publications with PXDN and Nervous System Diseases
 Leukemia, Myeloid, Acute Antibodies  >1 publications with PXDN and Leukemia, Myeloid, Acute

Organs/Tissues associated with anti-PXDN antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >3 publications with PXDN and Eye
 Heart Antibodies  >2 publications with PXDN and Heart
 Brain Antibodies  >2 publications with PXDN and Brain
 Vascular Antibodies  >1 publications with PXDN and Vascular
 Muscle Antibodies  >1 publications with PXDN and Muscle
 Liver Antibodies  >1 publications with PXDN and Liver
 Uterus Antibodies  >1 publications with PXDN and Uterus
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