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TBCA Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200154

Tubulin folding cofactor A, also known as TBCA, is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TBCA, Monoclonal Antibody
Full Product Name
TBCA antibody
Product Gene Name
anti-TBCA antibody
Product Synonym Names
Tubulin folding cofactor A; Tubulin folding cofactor A; chaperonin cofactor a; tubulin specific chaperone a; TBCA; Tubulin folding cofactor A CFA; Co chaperonin associated with a & b tubulin; Cofactor A; TCP1 chaperonin cofactor A; Tubulin cofactor a.
Clonality
Monoclonal
Isotype
IgG2b, k
Clone Number
AT1A5
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
Purity/Purification
By protein-G affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
15,792 Da
OMIM
AF038952 mRNA
3D Structure
ModBase 3D Structure for O75347
Antigen Species
Human
Immunogen
Recombinant TBCA (1-108aa) purified from E. coli
Clone Note
Anti-human TBCA mAb, clone AT1A5, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TBCA protein.

Product Categories/Family for anti-TBCA antibody

Cell Cycle
Applications Tested/Suitable for anti-TBCA antibody
ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-TBCA antibody
WB: 1:1000 ~ 2000.
Recommended starting dilution is 1:1000.

Western Blot (WB) of anti-TBCA antibody

The LNCap cell lysates (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TBCA antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. The Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human TBCA antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: HeLa cell lysate Lane 2.: K562 cell lysate
Mouse Anti-TBCA Monoclonal Antibody – Cat# MBS200154

Immunofluorescence (IF) of anti-TBCA antibody

ICC/IF analysis of TBCA in A549 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human TBCA antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green). ICC/IF analysis of TBCA in HeLa cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human TBCA antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
Mouse Anti-TBCA Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS200154

Product References and Citations for anti-TBCA antibody

Nolasco S, et al., (2005) FEBS Lett 579 (17):3515-3524; Tian G, et al., (1996) Cell 86 (2):287-296

Other Notes

Small volumes of anti-TBCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TBCA purchase

MBS200154 is an antibody targeting TBCA. Also known as TBCA antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TBCA. It may not necessarily be applicable to this product.

NCBI GI #
4759212
NCBI GeneID
6902
NCBI Accession #
NP_004598
UniProt Primary Accession #
O75347
UniProt Secondary Accession #
B4DT30
UniProt Related Accession #
O75347
GenBank Nucleotide #
NM_004607.2
NCBI Official Full Name
tubulin-specific chaperone A isoform 2
NCBI Official Synonym Full Names
tubulin folding cofactor A
NCBI Official Symbol
TBCA
UniProt Protein Name
Tubulin-specific chaperone A
UniProt Synonym Protein Names
TCP1-chaperonin cofactor A; Tubulin-folding cofactor A; CFA
UniProt Gene Name
TBCA
UniProt Synonym Gene Names
CFA
NCBI Protein Information
tubulin-specific chaperone A

NCBI Summary for TBCA

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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UniProt Comments for TBCA

Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Research Articles on TBCA

1. overexpression of TBCA did not induce biocharacteristics that directly contrasted to those of TBCA knockdown

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TBCA antibody

 Reference Product  PubMed Publications
 TBCD antibody  >7 publications with TBCA and TBCD
 TBCE antibody  >7 publications with TBCA and TBCE

Pathways associated with anti-TBCA antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-chaperonin Tubulin Folding Pathway antibodies  Post-chaperonin Tubulin Folding Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram

Diseases associated with anti-TBCA antibody

 Disease Name  Pubmed Publications
 Weight Loss Antibodies  >7 publications with TBCA and Weight Loss
 Bone Resorption Antibodies  >7 publications with TBCA and Bone Resorption
 Reperfusion Injury Antibodies  >5 publications with TBCA and Reperfusion Injury
 Heart Diseases Antibodies  >5 publications with TBCA and Heart Diseases
 Kidney Diseases Antibodies  >4 publications with TBCA and Kidney Diseases
 Hemorrhage Antibodies  >2 publications with TBCA and Hemorrhage
 Weight Gain Antibodies  >2 publications with TBCA and Weight Gain
 Inflammation Antibodies  >2 publications with TBCA and Inflammation
 Cognition Disorders Antibodies  >2 publications with TBCA and Cognition Disorders
 Hypertension Antibodies  >1 publications with TBCA and Hypertension

Organs/Tissues associated with anti-TBCA antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >42 publications with TBCA and Bone
 Connective Tissue Antibodies  >26 publications with TBCA and Connective Tissue
 Brain Antibodies  >16 publications with TBCA and Brain
 Blood Antibodies  >9 publications with TBCA and Blood
 Muscle Antibodies  >8 publications with TBCA and Muscle
 Kidney Antibodies  >5 publications with TBCA and Kidney
 Vascular Antibodies  >4 publications with TBCA and Vascular
 Heart Antibodies  >4 publications with TBCA and Heart
 Prostate Antibodies  >3 publications with TBCA and Prostate
 Lung Antibodies  >2 publications with TBCA and Lung
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