Adenomatosis Polyposis Coli Protein (APC) Antibody – Rabbit Polyclonal

APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 18p12

Cellular Component: axon; axonal growth cone; beta-catenin destruction complex; bicellular tight junction; catenin complex; cell cortex; cell projection; cell projection membrane; cell soma; cell-cell adherens junction; centrosome; cytoplasm; cytoplasmic microtubule; dendrite; growth cone; kinetochore; lamellipodium; lateral plasma membrane; microtubule; neuron projection; neuron projection terminus; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; Scrib-APC-beta-catenin complex; synapse

Molecular Function: beta-catenin binding; cadherin binding; gamma-catenin binding; identical protein binding; microtubule binding; microtubule plus-end binding; protease binding; protein binding; protein complex binding; protein kinase binding; protein kinase regulator activity; ubiquitin protein ligase binding

Biological Process: anterior/posterior pattern specification; axis specification; axonogenesis; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of apoptotic process; cell cycle arrest; cell migration; cellular response to DNA damage stimulus; chromosome organization and biogenesis; cytoplasmic microtubule organization; dorsal/ventral pattern formation; establishment and/or maintenance of cell polarity; hair follicle development; insulin receptor signaling pathway; kidney development; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle spindle assembly checkpoint; mitotic cytokinesis; muscle maintenance; negative regulation of apoptosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation; negative regulation of MAPKKK cascade; negative regulation of microtubule depolymerization; negative regulation of odontogenesis; negative regulation of Wnt signaling pathway; neuron projection development; pancreas development; pattern specification process; positive regulation of apoptosis; positive regulation of cell adhesion; positive regulation of cell death; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cell migration; positive regulation of epithelial cell differentiation; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of protein localization to centrosome; positive regulation of pseudopodium assembly; protein complex assembly; protein homooligomerization; proximal/distal pattern formation; regulation of attachment of spindle microtubules to kinetochore; regulation of cell cycle; regulation of cell differentiation; regulation of cell migration; regulation of epithelial cell differentiation; regulation of glutamate metabolic process; regulation of microtubule-based process; regulation of nitrogen compound metabolic process; regulation of osteoblast differentiation; regulation of osteoclast differentiation; response to alcohol; response to drug; retina development in camera-type eye; skin development; somatic stem cell maintenance; stem cell maintenance; T cell differentiation in thymus; thymus development; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway