Fibronectin (FN) Antibody – Rabbit Polyclonal

FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1 C3|1 36.05 cM

Cellular Component: apical plasma membrane; basal lamina; basement membrane; endoplasmic reticulum-Golgi intermediate compartment; extracellular matrix; extracellular region; extracellular space; fibrinogen complex; proteinaceous extracellular matrix

Molecular Function: chaperone binding; enzyme binding; heparin binding; identical protein binding; integrin binding; mercury ion binding; protease activator activity; protease binding; protein binding; protein C-terminus binding; receptor binding

Biological Process: acute-phase response; angiogenesis; calcium-independent cell-matrix adhesion; cell activation; cell adhesion; cell-matrix adhesion; cell-substrate junction assembly; extracellular matrix organization; glial cell migration; integrin activation; interaction with other organism via secreted substance during symbiotic interaction; interaction with symbiont; negative regulation of apoptosis; peptide cross-linking; positive regulation of axon extension; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of fibroblast proliferation; regulation of cell shape; regulation of protein amino acid phosphorylation; wound healing