Toll Like Receptor 3 (TLR3) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: cell surface; cytoplasm; early endosome; endoplasmic reticulum membrane; endosome membrane; Golgi membrane; integral component of plasma membrane; intracellular; lysosomal membrane; membrane

Molecular Function: double-stranded RNA binding; identical protein binding; protein binding; receptor activity; transmembrane receptor activity

Biological Process: activation of NF-kappaB-inducing kinase; cellular response to exogenous dsRNA; cellular response to interferon-gamma; defense response to bacterium; defense response to virus; detection of virus; hyperosmotic response; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; inflammatory response; innate immune response; male gonad development; microglial cell activation involved in immune response; MyD88-independent toll-like receptor signaling pathway; necroptotic process; negative regulation of MyD88-independent toll-like receptor signaling pathway; negative regulation of osteoclast differentiation; positive regulation of apoptosis; positive regulation of chemokine biosynthetic process; positive regulation of chemokine production; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of NF-kappaB transcription factor activity; positive regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of dendritic cell cytokine production; response to exogenous dsRNA; signal transduction; toll-like receptor 3 signaling pathway; toll-like receptor signaling pathway

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To