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CRABP1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200159

CRABP1 (cellular retinoic acid-binding protein 1) is a member of specific carrier proteins for members of the vitamin A family. CRABP1 is assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 is… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CRABP1, Monoclonal Antibody
Full Product Name
CRABP1 antibody
Product Gene Name
anti-CRABP1 antibody
Product Synonym Names
Cellular retinoic acid binding protein 1; CRABP; CRABP-I; CRABPI; RBP5; Cellular retinoic acid binding protein 1 CRABP 1; CRABP I; RBP 5; Retinoic acid binding protein I cellular.
Clonality
Monoclonal
Isotype
IgG2b, k
Clone Number
AT1A1
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
Purity/Purification
By protein-G affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
15,566 Da
OMIM
S74445 mRNA
3D Structure
ModBase 3D Structure for P29762
Antigen Species
Human
Immunogen
Recombinant human CRABP1 (1-137aa) purified from E. coli
Clone Note
Anti-human CRABP1 mAb, clone AT1A1, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CRABP1 protein.

Product Categories/Family for anti-CRABP1 antibody

Signal Transduction
Applications Tested/Suitable for anti-CRABP1 antibody
ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-CRABP1 antibody
WB: 1:500 ~ 1000.
Recommended starting dilution is 1:500

Western Blot (WB) of anti-CRABP1 antibody

The extracts of mouse eye (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CRABP1 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. The Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CRABP1 antibody (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1. : MCF-7 cell lysate The cell lysates (20ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CRABP1 antibody (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: 293T cell lysate Lane 2.: CRABP1 transfected 293T cell lysate
Mouse Anti-CRABP1 Monoclonal Antibody – Cat# MBS200159

Immunofluorescence (IF) of anti-CRABP1 antibody

ICC/IF analysis of CRABP1 in Balb/3T3 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human CRABP1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
Mouse Anti-CRABP1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS200159

Product References and Citations for anti-CRABP1 antibody

Wang L, et al. (1997) J Biol Chem, 272 (3):1541-7;. Nezzar H, et al. (2007) Mol Vis, 13:1641-50.

Other Notes

Small volumes of anti-CRABP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRABP1 purchase

MBS200159 is an antibody targeting CRABP1. Also known as CRABP1 antibody. Reactive in Human, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CRABP1. It may not necessarily be applicable to this product.

NCBI GI #
4758052
NCBI GeneID
1381
NCBI Accession #
NP_004369
UniProt Primary Accession #
P29762
UniProt Secondary Accession #
Q6IAY7; Q8WTV5
UniProt Related Accession #
P29762
GenBank Nucleotide #
NM_004378.2
NCBI Official Full Name
cellular retinoic acid-binding protein 1
NCBI Official Synonym Full Names
cellular retinoic acid binding protein 1
NCBI Official Symbol
CRABP1
NCBI Official Synonym Symbols
RBP5; CRABP; CRABPI; CRABP-I
UniProt Protein Name
Cellular retinoic acid-binding protein 1
UniProt Synonym Protein Names
Cellular retinoic acid-binding protein I; CRABP-I
Protein Family
Cellular retinoic acid-binding protein
UniProt Gene Name
CRABP1
UniProt Synonym Gene Names
RBP5; CRABP-I
NCBI Protein Information
cellular retinoic acid-binding protein 1

NCBI Summary for CRABP1

This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
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UniProt Comments for CRABP1

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

Research Articles on CRABP1

1. Holo-CRABPs had higher affinity for CYP26B1 than free atRA, but both apo-CRABPs(CRABP-I and CRABP-II ) inhibited the formation of 4-OH-RA by CYP26B1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRABP1 antibody

 Reference Product  PubMed Publications
 CACNA1G antibody  >41 publications with CRABP1 and CACNA1G
 CYP26B1 antibody  >7 publications with CRABP1 and CYP26B1
 CYP26A1 antibody  >5 publications with CRABP1 and CYP26A1
 RARS antibody  >4 publications with CRABP1 and RARS
 RBP3 antibody  >1 publications with CRABP1 and RBP3

Pathways associated with anti-CRABP1 antibody

 Products by Pathway  Pathway Diagram
 RA Biosynthesis Pathway antibodies  RA Biosynthesis Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Retinoic Acid Pathway antibodies  Signaling By Retinoic Acid Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram

Diseases associated with anti-CRABP1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >12 publications with CRABP1 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >5 publications with CRABP1 and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >4 publications with CRABP1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >4 publications with CRABP1 and Neoplasm Metastasis
 Inflammation Antibodies  >3 publications with CRABP1 and Inflammation
 Neoplasms, Experimental Antibodies  >3 publications with CRABP1 and Neoplasms, Experimental
 Fatty Liver Antibodies  >2 publications with CRABP1 and Fatty Liver
 Necrosis Antibodies  >2 publications with CRABP1 and Necrosis
 Disease Models, Animal Antibodies  >2 publications with CRABP1 and Disease Models, Animal
 Brain Diseases Antibodies  >2 publications with CRABP1 and Brain Diseases

Organs/Tissues associated with anti-CRABP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >11 publications with CRABP1 and Thyroid
 Embryonic Tissue Antibodies  >10 publications with CRABP1 and Embryonic Tissue
 Blood Antibodies  >6 publications with CRABP1 and Blood
 Brain Antibodies  >6 publications with CRABP1 and Brain
 Connective Tissue Antibodies  >5 publications with CRABP1 and Connective Tissue
 Bone Antibodies  >4 publications with CRABP1 and Bone
 Muscle Antibodies  >4 publications with CRABP1 and Muscle
 Testis Antibodies  >3 publications with CRABP1 and Testis
 Heart Antibodies  >3 publications with CRABP1 and Heart
 Prostate Antibodies  >3 publications with CRABP1 and Prostate
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