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Colony Stimulating Factor 3, Granulocyte (GCSF) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001595
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MBS2001595 is an antibody targeting GCSF. Also known as Polyclonal Antibody to Colony Stimulating Factor 3, Granulocyte (GCSF). Reactive in Mouse. Host: Rabbit. More details

$180 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Colony Stimulating Factor 3, Granulocyte (GCSF), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Colony Stimulating Factor 3, Granulocyte (GCSF)
Product Gene Name
anti-GCSF antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQ GPLGSEF- EQVRKI QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC SSQALQQTQC LSQLHSGLCL YQGLLQALSG ISPALAPTLD LLQLDVANFA TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF QRRAGGVLAI SYLQGFLETA RLALHH
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
1mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against GCSF. It has been selected for its ability to recognize GCSF in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: GCSF (MBS2001595)
Immunogen: GCSF (MBS2011596)
Matching Pairs
Unconjugated Antibody: GCSF (MBS2001595)
APC-CY7 Conjugated Antibody: GCSF (MBS2035812)
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Molecular Weight
22,421 Da
3D Structure
ModBase 3D Structure for P09920
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant GCSF (Glu55~His206) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2035814
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-GCSF antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-GCSF antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-GCSF antibody

Western Blot: Sample: Recombinant GCSF, Mouse.
Rabbit Anti-GCSF Polyclonal Antibody – Cat# MBS2001595

Immunohistochemistry (IHC) of anti-GCSF antibody

DABstainingonIHC-P.Samples:MouseTissue)
Rabbit Anti-GCSF Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001595

Other Notes

Small volumes of anti-GCSF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GCSF. It may not necessarily be applicable to this product.

NCBI GI #
6753536
NCBI GeneID
12985
NCBI Accession #
NP_034101.1
UniProt Primary Accession #
P09920
UniProt Related Accession #
P09920
GenBank Nucleotide #
NM_009971.1
NCBI Official Full Name
granulocyte colony-stimulating factor
NCBI Official Synonym Full Names
colony stimulating factor 3 (granulocyte)
NCBI Official Symbol
Csf3
NCBI Official Synonym Symbols
Csfg; G-CSF; MGI-IG
UniProt Protein Name
Granulocyte colony-stimulating factor
UniProt Gene Name
Csf3
UniProt Synonym Gene Names
Csfg; G-CSF
NCBI Protein Information
granulocyte colony-stimulating factor

UniProt Comments for GCSF

G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11 D|11 62.45 cM

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; enzyme binding; granulocyte colony-stimulating factor receptor binding; growth factor activity

Biological Process: granulocyte differentiation; immune response; macrophage differentiation; neutrophil differentiation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of myeloid cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein binding; positive regulation of protein kinase B signaling; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter
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Research Articles on GCSF

1. these data provide strong evidence for a role for G-CSF in the development of ACI after burn injury through suppression of EPO signaling in bone marrow erythroid cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GCSF antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-GCSF antibody

 Disease Name  Pubmed Publications
 Disease Susceptibility Antibodies  >6 publications with GCSF and Disease Susceptibility
 Nervous System Diseases Antibodies  >5 publications with GCSF and Nervous System Diseases
 Breast Neoplasms Antibodies  >3 publications with GCSF and Breast Neoplasms
 Neutropenia Antibodies  >3 publications with GCSF and Neutropenia
 Leukopenia Antibodies  >2 publications with GCSF and Leukopenia
 Anemia Antibodies  >2 publications with GCSF and Anemia
 Neoplasm Metastasis Antibodies  >2 publications with GCSF and Neoplasm Metastasis
 Leukemia, Myeloid, Acute Antibodies  >2 publications with GCSF and Leukemia, Myeloid, Acute
 Peripheral Nervous System Diseases Antibodies  >1 publications with GCSF and Peripheral Nervous System Diseases
 Pulmonary Fibrosis Antibodies  >1 publications with GCSF and Pulmonary Fibrosis

Organs/Tissues associated with anti-GCSF antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with GCSF and Lung
 Mammary Gland Antibodies  >3 publications with GCSF and Mammary Gland
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