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FK506 Binding Protein 10 (FKBP10) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001637
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MBS2001637 is an antibody targeting FKBP10. Also known as Polyclonal Antibody to FK506 Binding Protein 10 (FKBP10). Reactive in Human, Rat. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FK506 Binding Protein 10 (FKBP10), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to FK506 Binding Protein 10 (FKBP10)
Product Gene Name
anti-FKBP10 antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-VST LLRPPHCPRM VQDGDFVRYH YNGTLLDGTS FDTSYSKGGT YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK GYGTVIPPQA SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG ENGTGDKIPG SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD FVRYHYNCSL LDGTQLFTSH DYGAPQEATL GANKVIEGLD
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against FKBP10. It has been selected for its ability to recognize FKBP10 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: FKBP10 (MBS2001637)
Immunogen: FKBP10 (MBS2009161)
Matching Pairs
Unconjugated Antibody: FKBP10 (MBS2001637)
APC-CY7 Conjugated Antibody: FKBP10 (MBS2075078)
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Molecular Weight
38,950 Da
OMIM
AF337909 mRNA
3D Structure
ModBase 3D Structure for Q96AY3
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant FKBP10 (Val158~Asp440) expressed in E.coli.
Cross Reactivity
Human, Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2075080
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-FKBP10 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-FKBP10 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-FKBP10 antibody

Western Blot: Sample: Rat Placenta lysate; Primary Ab: 1ug/ml Rabbit Anti-Human FKBP10 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-FKBP10 Polyclonal Antibody – Cat# MBS2001637

Western Blot (WB) of anti-FKBP10 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-FKBP10 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2001637

Immunohistochemistry (IHC) of anti-FKBP10 antibody

DAB staining on IHC-P. Samples: Human Tissue)
Rabbit Anti-FKBP10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001637

Other Notes

Small volumes of anti-FKBP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP10. It may not necessarily be applicable to this product.

NCBI GI #
192448443
NCBI GeneID
60681
NCBI Accession #
NP_068758.3
UniProt Primary Accession #
Q96AY3
UniProt Secondary Accession #
Q7Z3R4; Q9H3N3; Q9H6J3; Q9H6N5; Q9UF89
UniProt Related Accession #
Q96AY3
GenBank Nucleotide #
NM_021939.3
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase FKBP10
NCBI Official Synonym Full Names
FK506 binding protein 10
NCBI Official Symbol
FKBP10
NCBI Official Synonym Symbols
OI6; OI11; BRKS1; FKBP65; PPIASE; hFKBP65
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP10
UniProt Synonym Protein Names
65 kDa FK506-binding protein; 65 kDa FKBP; FKBP-65; FK506-binding protein 10; FKBP-10; Immunophilin FKBP65; Rotamase
Protein Family
Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name
FKBP10
UniProt Synonym Gene Names
FKBP65; PPIase FKBP10; 65 kDa FKBP; FKBP-65; FKBP-10
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP10

NCBI Summary for FKBP10

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
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UniProt Comments for FKBP10

FKBP10: PPIases accelerate the folding of proteins during protein synthesis. Defects in FKBP10 are the cause of osteogenesis imperfecta type 6 (OI6). OI6 is a moderate to severe, autosomal recessive form of osteogenesis imperfecta characterized by increased serum alkaline phosphatase levels and bone histology exhibiting a fish scale-like lamellar pattern. Osteogenesis imperfecta defines a group of connective tissue disorders characterized by bone fragility and low bone mass.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; endoplasmic reticulum lumen; nucleolus

Molecular Function: calcium ion binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity

Biological Process: histone peptidyl-prolyl isomerization

Disease: Bruck Syndrome 1; Osteogenesis Imperfecta, Type Xi
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Research Articles on FKBP10

1. FKBP10 protein is overexpressed in renal cell carcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-FKBP10 antibody

 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >4 publications with FKBP10 and Muscular Diseases
 Neoplasms Antibodies  >2 publications with FKBP10 and Neoplasms
 Adenocarcinoma Antibodies  >1 publications with FKBP10 and Adenocarcinoma
 Craniofacial Abnormalities Antibodies  >1 publications with FKBP10 and Craniofacial Abnormalities
 Neoplasm Metastasis Antibodies  >1 publications with FKBP10 and Neoplasm Metastasis
 Weight Gain Antibodies  >1 publications with FKBP10 and Weight Gain
 Mental Disorders Antibodies  >1 publications with FKBP10 and Mental Disorders
 Gonadal Disorders Antibodies  >1 publications with FKBP10 and Gonadal Disorders
 Fibrosis Antibodies  >1 publications with FKBP10 and Fibrosis
 Lung Diseases Antibodies  >1 publications with FKBP10 and Lung Diseases

Organs/Tissues associated with anti-FKBP10 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with FKBP10 and Bone
 Lung Antibodies  >5 publications with FKBP10 and Lung
 Vascular Antibodies  >3 publications with FKBP10 and Vascular
 Muscle Antibodies  >3 publications with FKBP10 and Muscle
 Connective Tissue Antibodies  >2 publications with FKBP10 and Connective Tissue
 Skin Antibodies  >2 publications with FKBP10 and Skin
 Adrenal Gland Antibodies  >1 publications with FKBP10 and Adrenal Gland
 Heart Antibodies  >1 publications with FKBP10 and Heart
 Uterus Antibodies  >1 publications with FKBP10 and Uterus
 Embryonic Tissue Antibodies  >1 publications with FKBP10 and Embryonic Tissue
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