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Casein Kinase 1 Alpha (CSNK1A1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200165

Caseine Kinase 1 alpha belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily. CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cellular processes including… More details

$285 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Casein Kinase 1 alpha (CSNK1A1), Monoclonal Antibody
Full Product Name
Casein Kinase 1 alpha antibody
Product Gene Name
anti-CSNK1A1 antibody
Product Synonym Names
Casein Kinase 1 alpha; CK1
Clonality
Monoclonal
Isotype
IgG2b, kappa
Clone Number
AT2E2
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
Purity/Purification
By protein-G affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at 2-8°C for 1 week. For long term storage , aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
OMIM
X80693 mRNA
3D Structure
ModBase 3D Structure for P48729
Immunogen
Recombinant human Casein Kinase 1 alpha (1-337aa) purified from E. coli

Product Categories/Family for anti-CSNK1A1 antibody

Signal Transduction
Applications Tested/Suitable for anti-CSNK1A1 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Western Blot (WB) of anti-CSNK1A1 antibody

Figure 1:
The cell lysates of HeLa and MCF7 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Casein Kinase 1 alpha (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Figure 2:
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Caseine kinase 1 alpha antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Jurkat cell lysate
Mouse Anti-CSNK1A1 Monoclonal Antibody – Cat# MBS200165

Immunofluorescence (IF) of anti-CSNK1A1 antibody

ICC/IF analysis of Casein Kinase 1 alpha in HeLa cells line, stained with MBS200165 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stainied the cell nucleus (blue)
Mouse Anti-CSNK1A1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS200165

Product References and Citations for anti-CSNK1A1 antibody

Knippschild U, et al., (2005) Onkologie. 28 (10):508-14; Katoh M., (2007) Clin Cancer Res. 13 (14):4042-5

Other Notes

Small volumes of anti-CSNK1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CSNK1A1 purchase

MBS200165 is an antibody targeting CSNK1A1. Also known as Casein Kinase 1 alpha antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CSNK1A1. It may not necessarily be applicable to this product.

NCBI GI #
68303572
NCBI GeneID
1452
NCBI Accession #
NP_001883
UniProt Primary Accession #
P48729
UniProt Secondary Accession #
Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3; D3DQG0; D3DQG1
UniProt Related Accession #
P48729
GenBank Nucleotide #
NM_001892.5
NCBI Official Full Name
casein kinase I isoform alpha isoform 2
NCBI Official Synonym Full Names
casein kinase 1 alpha 1
NCBI Official Symbol
CSNK1A1
NCBI Official Synonym Symbols
CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
UniProt Protein Name
Casein kinase I isoform alpha
UniProt Synonym Protein Names
CK1
Protein Family
Casein kinase
UniProt Gene Name
CSNK1A1
UniProt Synonym Gene Names
CKI-alpha
NCBI Protein Information
casein kinase I isoform alpha

UniProt Comments for CSNK1A1

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
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Research Articles on CSNK1A1

1. casein kinase 1 phosphorylates the SQSTM1 S349 residue when harmful proteins accumulate under HSF1 stress

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CSNK1A1 antibody

 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 Beta-catenin Phosphorylation Cascade Pathway antibodies  Beta-catenin Phosphorylation Cascade Pathway Diagram
 Breast Cancer Pathway antibodies  Breast Cancer Pathway Diagram
 Breast Cancer Pathway antibodies  Breast Cancer Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Degradation Of GLI2 By The Proteasome Pathway antibodies  Degradation Of GLI2 By The Proteasome Pathway Diagram

Diseases associated with anti-CSNK1A1 antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >2 publications with CSNK1A1 and Prostatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with CSNK1A1 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >2 publications with CSNK1A1 and Disease Models, Animal
 Hyperplasia Antibodies  >2 publications with CSNK1A1 and Hyperplasia
 Nervous System Diseases Antibodies  >1 publications with CSNK1A1 and Nervous System Diseases
 Cognition Disorders Antibodies  >1 publications with CSNK1A1 and Cognition Disorders
 Anemia Antibodies  >1 publications with CSNK1A1 and Anemia
 Inflammation Antibodies  >1 publications with CSNK1A1 and Inflammation
 Leukemia-Lymphoma, Adult T-Cell Antibodies  >1 publications with CSNK1A1 and Leukemia-Lymphoma, Adult T-Cell

Organs/Tissues associated with anti-CSNK1A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with CSNK1A1 and Blood
 Lung Antibodies  >6 publications with CSNK1A1 and Lung
 Bone Antibodies  >4 publications with CSNK1A1 and Bone
 Skin Antibodies  >4 publications with CSNK1A1 and Skin
 Prostate Antibodies  >3 publications with CSNK1A1 and Prostate
 Bone Marrow Antibodies  >3 publications with CSNK1A1 and Bone Marrow
 Lymph Node Antibodies  >2 publications with CSNK1A1 and Lymph Node
 Intestine Antibodies  >2 publications with CSNK1A1 and Intestine
 Brain Antibodies  >2 publications with CSNK1A1 and Brain
 Bladder Antibodies  >1 publications with CSNK1A1 and Bladder
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