Annexin A2 (ANXA2) Antibody – Rabbit Polyclonal

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ANXA2: a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q22.2

Cellular Component: basement membrane; basolateral plasma membrane; cell cortex; cell surface; cell-cell adherens junction; cytoplasm; cytosol; early endosome; endosome; extracellular exosome; extracellular matrix; extracellular region; extracellular space; extrinsic component of plasma membrane; late endosome membrane; lipid droplet; lysosomal membrane; macropinosome; melanosome; membrane; membrane raft; midbody; nucleus; PCSK9-AnxA2 complex; perinuclear region of cytoplasm; plasma membrane; ruffle; sarcolemma; vesicle

Molecular Function: bone sialoprotein binding; cadherin binding involved in cell-cell adhesion; calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; cytoskeletal protein binding; identical protein binding; molecular function regulator; phosphatidylinositol-4,5-bisphosphate binding; phospholipase A2 inhibitor activity; protease binding; protein binding; Rab GTPase binding; RNA binding; S100 protein binding

Biological Process: angiogenesis; body fluid secretion; catabolism by host of symbiont protein; collagen fibril organization; fibrinolysis; lipid raft formation; membrane budding; negative regulation by host of symbiont molecular function; negative regulation of catalytic activity; negative regulation of low-density lipoprotein particle receptor catabolic process; neutrophil degranulation; positive regulation of fibroblast proliferation; positive regulation of low-density lipoprotein particle clearance; positive regulation of low-density lipoprotein particle receptor binding; positive regulation of low-density lipoprotein receptor activity; positive regulation of protein phosphorylation; positive regulation of receptor recycling; positive regulation of receptor-mediated endocytosis involved in cholesterol transport; positive regulation of vesicle fusion; protein heterotetramerization; protein localization to plasma membrane